Structure analysis

Crystal Structure Analysis of a 6-Amino Quinazolinedione Sulfonamide bound to human GluR2

X-ray diffraction
1.9Å resolution
Source organism: Homo sapiens
Assembly composition:
homo dimer (preferred)
Entry contents: 1 distinct polypeptide molecule

Assemblies

Assembly 1 (preferred)
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Multimeric state: homo dimer
Accessible surface area: 23426.96 Å2
Buried surface area: 2450.11 Å2
Dissociation area: 1,225.06 Å2
Dissociation energy (ΔGdiss): 3.36 kcal/mol
Dissociation entropy (TΔSdiss): 13.44 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-154589

Macromolecules

PDBe-KB: UniProt Coverage View: P42262  
126320406080100120140160180200220240260
 
100200GPNKTVVVTTILESPYVMMKKNHEMLEGNERYEGYCVDLAAEIAKHCGFKYKLTIVGDGKYGARDADTKIWNGMVGELVYGKADIAIAPLTITLVREEVIDFSKPFMSLGISIMIKKGTPIESAEDLSKQTEIAYGTLDSGSTKEFFRRSKIAVFDKMWTYMRSAEPSVFVRTTAEGVARVRKSKGKYAYLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGIATPKGSSLRNAVNLAVLKLNEQGLLDKLKNKWWYDKGECGS
UniProt
P42262
Chains
Domains
Secondary structure
Flexibility predictions
Early folding residue predictions
Ligand binding sites
Interaction interfaces
Sequence conservation

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