EC 2.1.1.45: Thymidylate synthase
Reaction catalysed:
5,10-methylenetetrahydrofolate + dUMP = dihydrofolate + dTMP
Systematic name:
5,10-methylenetetrahydrofolate:dUMP C-methyltransferase
Alternative Name(s):
- Methylenetetrahydrofolate:dUMP C-methyltransferase
- TMP synthetase
- Thymidylate synthetase
- dTMP synthase
EC 1.5.1.3: Dihydrofolate reductase
Reaction catalysed:
5,6,7,8-tetrahydrofolate + NADP(+) = 7,8-dihydrofolate + NADPH
Systematic name:
5,6,7,8-tetrahydrofolate:NADP(+) oxidoreductase
Alternative Name(s):
- 7,8-dihydrofolate reductase
- DHFR
- Dihydrofolate reductase:thymidylate synthase
- Dihydrofolic acid reductase
- Dihydrofolic reductase
- Folic acid reductase
- Folic reductase
- NADPH-dihydrofolate reductase
- Pteridine reductase:dihydrofolate reductase
- Tetrahydrofolate dehydrogenase
- Thymidylate synthetase-dihydrofolate reductase
GO terms
Biochemical function:
Biological process:
Cellular component:
- not assigned
Sequence families
Protein families (Pfam)
InterPro annotations
Structure domains
CATH domains
3.30.572.10
Class:
Alpha Beta
Architecture:
2-Layer Sandwich
Topology:
Thymidylate Synthase; Chain A
Homology:
Thymidylate synthase/dCMP hydroxymethylase domain
Occurring in:
![The deposited structure of PDB entry <span class='highlight'>3um5</span> contains 2 copies of CATH domain <span class='highlight'>3.30.572.10 (Thymidylate Synthase; Chain A)</span> in <span class='highlight'>Bifunctional dihydrofolate reductase-thymidylate synthase</span>. Showing 1 copy in chain <span class='highlight'>A</span>. The deposited structure of PDB entry 3um5 contains 2 copies of CATH domain 3.30.572.10 (Thymidylate Synthase; Chain A) in Bifunctional dihydrofolate reductase-thymidylate synthase. Showing 1 copy in chain A.](https://www.ebi.ac.uk/pdbe/static/entry/3um5_1_A_CATH_3.30.572.10_image-200x200.png)
6.10.250.2210
Class:
Special
Architecture:
Helix non-globular
Topology:
Single alpha-helices involved in coiled-coils or other helix-helix interfaces
Homology:
Single alpha-helices involved in coiled-coils or other helix-helix interfaces
Occurring in:
![The deposited structure of PDB entry <span class='highlight'>3um5</span> contains 2 copies of CATH domain <span class='highlight'>6.10.250.2210 (Single alpha-helices involved in coiled-coils or other helix-helix interfaces)</span> in <span class='highlight'>Bifunctional dihydrofolate reductase-thymidylate synthase</span>. Showing 1 copy in chain <span class='highlight'>A</span>. The deposited structure of PDB entry 3um5 contains 2 copies of CATH domain 6.10.250.2210 (Single alpha-helices involved in coiled-coils or other helix-helix interfaces) in Bifunctional dihydrofolate reductase-thymidylate synthase. Showing 1 copy in chain A.](https://www.ebi.ac.uk/pdbe/static/entry/3um5_1_A_CATH_6.10.250.2210_image-200x200.png)