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Crystal structure of WDR5 in complex with the WDR5-interacting motif of MLL2

X-ray diffraction
1.4Å resolution
PDB entry 3uvk coloured by chain, front view.
PDB entry 3uvk coloured by chain, side view.
PDB entry 3uvk coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero dimer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: WD repeat-containing protein 5 and Histone-lysine N-methyltransferase 2D
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Multimeric state: hetero dimer
Accessible surface area: 12015.08 Å2
Buried surface area: 1959.1 Å2
Dissociation area: 631.08 Å2
Dissociation energy (ΔGdiss): 3.73 kcal/mol
Dissociation entropy (TΔSdiss): 7.52 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-127056

Macromolecules

WD repeat-containing protein 5
Chain: A
Length: 318 amino acids
Theoretical weight: 34.79 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P61964 (Residues: 21-334; Coverage: 94%)
Gene names: BIG3, WDR5
Pfam: WD domain, G-beta repeat
InterPro:
CATH: YVTN repeat-like/Quinoprotein amine dehydrogenase
WD repeat-containing protein 5 in PDB entry 3uvk, assembly 1, front view.
WD repeat-containing protein 5 in PDB entry 3uvk, assembly 1, side view.
WD repeat-containing protein 5 in PDB entry 3uvk, assembly 1, top view.
PDBe-KB: UniProt Coverage View: P61964  
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Histone-lysine N-methyltransferase 2D
Chain: B
Length: 11 amino acids
Theoretical weight: 1.18 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: O14686 (Residues: 5337-5347; Coverage: 0%)
Gene names: ALR, KMT2D, MLL2, MLL4
Histone-lysine N-methyltransferase 2D in PDB entry 3uvk, assembly 1, front view.
Histone-lysine N-methyltransferase 2D in PDB entry 3uvk, assembly 1, side view.
Histone-lysine N-methyltransferase 2D in PDB entry 3uvk, assembly 1, top view.
PDBe-KB: UniProt Coverage View: O14686  
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