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Human caspase 9 in complex with bacterial effector protein

Source organisms:
Biochemical function: cysteine-type peptidase activity
Biological process: proteolysis
Cellular component: not assigned

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EC 3.4.22.62: Caspase-9

Reaction catalysed:
Strict requirement for an Asp residue at position P1 and with a marked preference for His at position P2. It has a preferred cleavage sequence of Leu-Gly-His-Asp-|-Xaa
Systematic name:
-
Alternative Name(s):
  • APAF-3
  • Apoptotic protease Mch-6
  • Apoptotic protease-activating factor 3
  • CASP-9
  • ICE-LAP6
  • ICE-like apoptotic protease 6

GO terms

Biochemical function:
Biological process:
Cellular component:
  • not assigned

Sequence families

Pfam Protein families (Pfam)
PF16809
Domain description: NleF caspase inhibitor
Occurring in:
  1. Effector protein NleF
The deposited structure of PDB entry 3v3k contains 8 copies of Pfam domain PF16809 (NleF caspase inhibitor) in Effector protein NleF. Showing 1 copy in chain B.

PF00656
Domain description: Caspase domain
Occurring in:
  1. Caspase-9 subunit p35
The deposited structure of PDB entry 3v3k contains 8 copies of Pfam domain PF00656 (Caspase domain) in Caspase-9 subunit p35. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR015917
Domain description: Peptidase C14A, caspase catalytic domain
Occurring in:
  1. Caspase-9 subunit p35
IPR031829
Domain description: Effector protein NleF
Occurring in:
  1. Effector protein NleF
IPR038334
Domain description: NleF superfamily
Occurring in:
  1. Effector protein NleF
IPR002138
Domain description: Peptidase C14, caspase non-catalytic subunit p10
Occurring in:
  1. Caspase-9 subunit p35
IPR033139
Domain description: Peptidase family C14A, cysteine active site
Occurring in:
  1. Caspase-9 subunit p35
IPR016129
Domain description: Peptidase family C14A, His active site
Occurring in:
  1. Caspase-9 subunit p35
IPR011600
Domain description: Peptidase C14, caspase domain
Occurring in:
  1. Caspase-9 subunit p35
IPR001309
Domain description: Peptidase C14, p20 domain
Occurring in:
  1. Caspase-9 subunit p35
IPR002398
Domain description: Peptidase C14 family
Occurring in:
  1. Caspase-9 subunit p35
IPR029030
Domain description: Caspase-like domain superfamily
Occurring in:
  1. Caspase-9 subunit p35

Structure domains

CATH CATH domains
1.20.1260.90
Class: Mainly Alpha
Architecture: Up-down Bundle
Topology: Ferritin
Homology: Ferritin
Occurring in:
  1. Effector protein NleF
The deposited structure of PDB entry 3v3k contains 8 copies of CATH domain 1.20.1260.90 (Ferritin) in Effector protein NleF. Showing 1 copy in chain B.
3.40.50.1460
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Rossmann fold
Homology: Rossmann fold
Occurring in:
  1. Caspase-9 subunit p35
The deposited structure of PDB entry 3v3k contains 8 copies of CATH domain 3.40.50.1460 (Rossmann fold) in Caspase-9 subunit p35. Showing 1 copy in chain A.

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