› 3ve6

X-ray diffraction
2.83Å resolution

Crystal Structure Analysis of Venezuelan Equine Encephalitis Virus Capsid Protein NLS and Importin Alpha

Released:
DOI: 10.2210/pdb3ve6/pdb
PDB entry 3ve6 coloured by chain, front view.
PDB entry 3ve6 coloured by chain, side view.
PDB entry 3ve6 coloured by chain, top view.
Source organisms:
Entry author: Fan F

Function and Biology Details

Reaction catalysed: 
Autocatalytic release of the core protein from the N-terminus of the togavirus structural polyprotein by hydrolysis of a -Trp-|-Ser- bond.
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-531225 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Importin subunit alpha-1 Chain: A
Molecule details ›
Chain: A
Length: 426 amino acids
Theoretical weight: 46.18 KDa
Source organism: Mus musculus
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P52293 (Residues: 71-496; Coverage: 81%)
Gene names: Kpna2, Rch1
Sequence domains:
Structure domains: Leucine-rich Repeat Variant
Capsid protein Chain: B
Molecule details ›
Chain: B
Length: 12 amino acids
Theoretical weight: 1.27 KDa
Source organism: Venezuelan equine encephalitis virus
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P09592 (Residues: 59-70; Coverage: 1%)

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: AUSTRALIAN SYNCHROTRON BEAMLINE MX1
Spacegroup: P212121
Unit cell:
a: 78.95Å b: 89.75Å c: 99.58Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.228 0.226 0.27
Expression system: Escherichia coli BL21(DE3)

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