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Crystal Structure Analysis of Venezuelan Equine Encephalitis Virus Capsid Protein NLS and Importin Alpha

Source organisms:
Biochemical function: not assigned
Biological process: not assigned
Cellular component: not assigned

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EC 3.4.21.90: Togavirin

Reaction catalysed:
Autocatalytic release of the core protein from the N-terminus of the togavirus structural polyprotein by hydrolysis of a -Trp-|-Ser- bond.
Alternative Name(s):
  • NsP2 proteinase
  • Sindbis virus core protein
  • Sindbis virus protease

GO terms

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Sequence families

Pfam Protein families (Pfam)
PF00514
Domain description: Armadillo/beta-catenin-like repeat
Occurring in:
  1. Importin subunit alpha-1
The deposited structure of PDB entry 3ve6 contains 7 copies of Pfam domain PF00514 (Armadillo/beta-catenin-like repeat) in Importin subunit alpha-1. Showing 7 copies in chain A.

PF16186
Domain description: Atypical Arm repeat
Occurring in:
  1. Importin subunit alpha-1
The deposited structure of PDB entry 3ve6 contains 1 copy of Pfam domain PF16186 (Atypical Arm repeat ) in Importin subunit alpha-1. Showing 1 copy in chain A.

PF01749
Domain description: Importin beta binding domain
Occurring in:
  1. Importin subunit alpha-1
The deposited structure of PDB entry 3ve6 contains 1 copy of Pfam domain PF01749 (Importin beta binding domain) in Importin subunit alpha-1. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR000225
Domain description: Armadillo
Occurring in:
  1. Importin subunit alpha-1
IPR032413
Domain description: Atypical Arm repeat
Occurring in:
  1. Importin subunit alpha-1
IPR016024
Domain description: Armadillo-type fold
Occurring in:
  1. Importin subunit alpha-1
IPR011989
Domain description: Armadillo-like helical
Occurring in:
  1. Importin subunit alpha-1

Structure domain

CATH CATH domain
1.25.10.10
Class: Mainly Alpha
Architecture: Alpha Horseshoe
Topology: Leucine-rich Repeat Variant
Homology: Leucine-rich Repeat Variant
Occurring in:
  1. Importin subunit alpha-1
The deposited structure of PDB entry 3ve6 contains 1 copy of CATH domain 1.25.10.10 (Leucine-rich Repeat Variant) in Importin subunit alpha-1. Showing 1 copy in chain A.

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