› › Structure analysis

Crystal structure of human mdm2 with a dihydroimidazothiazole inhibitor

X-ray diffraction
1.9Å resolution
PDB entry 3w69 coloured by chain, front view.
PDB entry 3w69 coloured by chain, side view.
PDB entry 3w69 coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

Quick links

Assemblies

Assembly 1 (preferred)
Download    3D Visualisation
Assembly Name: E3 ubiquitin-protein ligase Mdm2
hide full assembly name
Multimeric state: monomeric
Accessible surface area: 5659.78 Å2
Buried surface area: 207.52 Å2
Dissociation area: 103.76 Å2
Dissociation energy (ΔGdiss): 17.51 kcal/mol
Dissociation entropy (TΔSdiss): 0.57 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-169499
Assembly 2
Download    3D Visualisation
Assembly Name: E3 ubiquitin-protein ligase Mdm2
hide full assembly name
Multimeric state: monomeric
Accessible surface area: 5882.48 Å2
Buried surface area: 375.31 Å2
Dissociation area: 94.26 Å2
Dissociation energy (ΔGdiss): 14.09 kcal/mol
Dissociation entropy (TΔSdiss): 0.58 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-169499

Macromolecules

E3 ubiquitin-protein ligase Mdm2
Chains: A, B
Length: 87 amino acids
Theoretical weight: 10.2 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q00987 (Residues: 25-109; Coverage: 17%)
  • Best match: Q00987-8 (Residues: 1-48)
Gene name: MDM2
Pfam: SWIB/MDM2 domain
InterPro:
CATH: SWIB/MDM2 domain
E3 ubiquitin-protein ligase Mdm2 in PDB entry 3w69, assembly 1, front view.
E3 ubiquitin-protein ligase Mdm2 in PDB entry 3w69, assembly 1, side view.
E3 ubiquitin-protein ligase Mdm2 in PDB entry 3w69, assembly 1, top view.
Molecule details ›

Search similar proteins

Quick links