› › Structure analysis

pVHL54-213-EloB-EloC complex_(2S,4R)-4-hydroxy-1-(2-(3-methylisoxazol- 5-yl)acetyl)-N-(4-nitrobenzyl)pyrrolidine-2-carboxamide bound

X-ray diffraction
2.5Å resolution
PDB entry 3zun coloured by chain, front view.
PDB entry 3zun coloured by chain, side view.
PDB entry 3zun coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero trimer (preferred)
Entry contents: 3 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Multimeric state: hetero trimer
Accessible surface area: 15540.7 Å2
Buried surface area: 4599.91 Å2
Dissociation area: 1,102.06 Å2
Dissociation energy (ΔGdiss): 11.24 kcal/mol
Dissociation entropy (TΔSdiss): 11.8 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-154086
Assembly 2
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Multimeric state: hetero trimer
Accessible surface area: 16107.83 Å2
Buried surface area: 4442.82 Å2
Dissociation area: 1,183.11 Å2
Dissociation energy (ΔGdiss): 10.92 kcal/mol
Dissociation entropy (TΔSdiss): 11.7 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-154086
Assembly 3
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Multimeric state: hetero trimer
Accessible surface area: 16081.26 Å2
Buried surface area: 4595.17 Å2
Dissociation area: 1,214.89 Å2
Dissociation energy (ΔGdiss): 16.01 kcal/mol
Dissociation entropy (TΔSdiss): 11.9 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-154086
Assembly 4
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Multimeric state: hetero trimer
Accessible surface area: 15861.68 Å2
Buried surface area: 4396.83 Å2
Dissociation area: 1,189.89 Å2
Dissociation energy (ΔGdiss): 12.41 kcal/mol
Dissociation entropy (TΔSdiss): 11.76 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-154086

Macromolecules

Elongin-B
Chains: A, D, G, J
Length: 118 amino acids
Theoretical weight: 13.15 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q15370 (Residues: 1-118; Coverage: 100%)
Gene names: ELOB, TCEB2
Pfam: Ubiquitin family
InterPro:
CATH: Phosphatidylinositol 3-kinase Catalytic Subunit; Chain A, domain 1
Elongin-B in PDB entry 3zun, assembly 1, front view.
Elongin-B in PDB entry 3zun, assembly 1, side view.
Elongin-B in PDB entry 3zun, assembly 1, top view.
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Elongin-C
Chains: B, E, H, K
Length: 97 amino acids
Theoretical weight: 10.97 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q15369 (Residues: 17-112; Coverage: 86%)
Gene names: ELOC, TCEB1
Pfam: Skp1 family, tetramerisation domain
InterPro:
CATH: Potassium Channel Kv1.1; Chain A
Elongin-C in PDB entry 3zun, assembly 1, front view.
Elongin-C in PDB entry 3zun, assembly 1, side view.
Elongin-C in PDB entry 3zun, assembly 1, top view.
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von Hippel-Lindau disease tumor suppressor
Chains: C, F, I, L
Length: 163 amino acids
Theoretical weight: 18.84 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P40337 (Residues: 54-213; Coverage: 75%)
Gene name: VHL
Pfam:
InterPro:
CATH:
von Hippel-Lindau disease tumor suppressor in PDB entry 3zun, assembly 1, front view.
von Hippel-Lindau disease tumor suppressor in PDB entry 3zun, assembly 1, side view.
von Hippel-Lindau disease tumor suppressor in PDB entry 3zun, assembly 1, top view.
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