› 4wzl

X-ray diffraction
1.7Å resolution

Crystal structure of P domain from norovirus strain Saga4 in complex with HBGA type Lea (triglycan)

Released:
DOI: 10.2210/pdb4wzl/pdb
PDB entry 4wzl coloured by chain, front view.
PDB entry 4wzl coloured by chain, side view.
PDB entry 4wzl coloured by chain, top view.
Source organism: Norovirus Hu/GII-4/Saga4/2006/JP
Primary publication:
Human noroviruses' fondness for histo-blood group antigens.
Singh BK, Leuthold MM, Hansman GS
J Virol 89 2024-40 (2015)
PMID: 25428879

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-110182 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (2 distinct):
VP1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 308 amino acids
Theoretical weight: 33.94 KDa
Source organism: Norovirus Hu/GII-4/Saga4/2006/JP
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: B5BTR7 (Residues: 225-530; Coverage: 57%)
Sequence domains: Calicivirus coat protein C-terminal
Structure domains:

Ligands and Environments

Carbohydrate polymer : NEW Components: NDG, GAL, FUC
Carbohydrate polymer
2 bound ligands:
Ligand EDO 9 x EDO
Ligand ACT 4 x ACT
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID23-1
Spacegroup: C2
Unit cell:
a: 96.87Å b: 58.83Å c: 124.44Å
α: 90° β: 119.8° γ: 90°
R-values:
R R work R free
0.172 0.17 0.196
Expression system: Escherichia coli BL21(DE3)

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Citations

16 review citations

Human Milk Oligosaccharides as Promising Antivirals.
Morozov et al. (2018)
15 more

1 mention without citation

Human noroviruses' fondness for histo-blood group antigens.
Singh et al. (2015)