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Crystal structure of putrescine transcarbamylase from Enterococcus faecalis with N5-(phosphonoacetyl)-L-ornithine

Source organism: Enterococcus faecalis
Biochemical function: putrescine carbamoyltransferase activity
Biological process: putrescine biosynthetic process from arginine via N-carbamoylputrescine
Cellular component: cytoplasm

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EC 2.1.3.6: Putrescine carbamoyltransferase

Reaction catalysed:
Carbamoyl phosphate + putrescine = phosphate + N-carbamoylputrescine
Systematic name:
Carbamoyl-phosphate:putrescine carbamoyltransferase
Alternative Name(s):
  • PTCase
  • Putrescine synthase
  • Putrescine transcarbamylase

GO terms

Sequence families

Pfam Protein families (Pfam)
PF00185
Domain description: Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain
Occurring in:
  1. Putrescine carbamoyltransferase
The deposited structure of PDB entry 4a8p contains 6 copies of Pfam domain PF00185 (Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain) in Putrescine carbamoyltransferase. Showing 1 copy in chain A.

PF02729
Domain description: Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain
Occurring in:
  1. Putrescine carbamoyltransferase
The deposited structure of PDB entry 4a8p contains 6 copies of Pfam domain PF02729 (Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain) in Putrescine carbamoyltransferase. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR002292
Domain description: Ornithine/putrescine carbamoyltransferase
Occurring in:
  1. Putrescine carbamoyltransferase
IPR006130
Domain description: Aspartate/ornithine carbamoyltransferase
Occurring in:
  1. Putrescine carbamoyltransferase
IPR036901
Domain description: Aspartate/ornithine carbamoyltransferase superfamily
Occurring in:
  1. Putrescine carbamoyltransferase
IPR024903
Domain description: Putrescine carbamoyltransferase PtcA
Occurring in:
  1. Putrescine carbamoyltransferase
IPR006131
Domain description: Aspartate/ornithine carbamoyltransferase, Asp/Orn-binding domain
Occurring in:
  1. Putrescine carbamoyltransferase
IPR006132
Domain description: Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding
Occurring in:
  1. Putrescine carbamoyltransferase

Structure domain

CATH CATH domain
3.40.50.1370
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Rossmann fold
Homology: Aspartate/ornithine carbamoyltransferase
Occurring in:
  1. Putrescine carbamoyltransferase
The deposited structure of PDB entry 4a8p contains 12 copies of CATH domain 3.40.50.1370 (Rossmann fold) in Putrescine carbamoyltransferase. Showing 2 copies in chain A.

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