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Crystal structure of the reactive loop cleaved ZPI in I2 space group

X-ray diffraction
2.09Å resolution
PDB entry 4afx coloured by chain, front view.
PDB entry 4afx coloured by chain, side view.
PDB entry 4afx coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero dimer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Protein Z-dependent protease inhibitor
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Multimeric state: hetero dimer
Accessible surface area: 17181.67 Å2
Buried surface area: 5812.36 Å2
Dissociation area: 2,456.82 Å2
Dissociation energy (ΔGdiss): 47.96 kcal/mol
Dissociation entropy (TΔSdiss): 10.73 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-193836

Macromolecules

Protein Z-dependent protease inhibitor
Chain: A
Length: 387 amino acids
Theoretical weight: 44.36 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q9UK55 (Residues: 23-408; Coverage: 91%)
Gene names: SERPINA10, UNQ707/PRO1358, ZPI
Pfam: Serpin (serine protease inhibitor)
InterPro:
CATH:
Protein Z-dependent protease inhibitor in PDB entry 4afx, assembly 1, front view.
Protein Z-dependent protease inhibitor in PDB entry 4afx, assembly 1, side view.
Protein Z-dependent protease inhibitor in PDB entry 4afx, assembly 1, top view.
PDBe-KB: UniProt Coverage View: Q9UK55  
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Protein Z-dependent protease inhibitor
Chain: B
Length: 36 amino acids
Theoretical weight: 4.17 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q9UK55 (Residues: 409-444; Coverage: 9%)
Gene names: SERPINA10, UNQ707/PRO1358, ZPI
InterPro:
Protein Z-dependent protease inhibitor in PDB entry 4afx, assembly 1, front view.
Protein Z-dependent protease inhibitor in PDB entry 4afx, assembly 1, side view.
Protein Z-dependent protease inhibitor in PDB entry 4afx, assembly 1, top view.
PDBe-KB: UniProt Coverage View: Q9UK55  
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