› › Function and Biology

Crystal structure of the human KLHL11-Cul3 complex at 2.8A resolution

Source organism: Homo sapiens
Biochemical function: ubiquitin protein ligase binding
Biological process: ubiquitin-dependent protein catabolic process
Cellular component: not assigned

Quick links

GO terms

Biochemical function:
Biological process:
Cellular component:
  • not assigned

Sequence families

Pfam Protein families (Pfam)
PF00888
Domain description: Cullin family
Occurring in:
  1. Cullin-3
The deposited structure of PDB entry 4ap2 contains 1 copy of Pfam domain PF00888 (Cullin family) in Cullin-3. Showing 1 copy in chain B.

PF07707
Domain description: BTB And C-terminal Kelch
Occurring in:
  1. Kelch-like protein 11
The deposited structure of PDB entry 4ap2 contains 1 copy of Pfam domain PF07707 (BTB And C-terminal Kelch) in Kelch-like protein 11. Showing 1 copy in chain A.

PF00651
Domain description: BTB/POZ domain
Occurring in:
  1. Kelch-like protein 11
The deposited structure of PDB entry 4ap2 contains 1 copy of Pfam domain PF00651 (BTB/POZ domain) in Kelch-like protein 11. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR000210
Domain description: BTB/POZ domain
Occurring in:
  1. Kelch-like protein 11
IPR011333
Domain description: SKP1/BTB/POZ domain superfamily
Occurring in:
  1. Kelch-like protein 11
IPR001373
Domain description: Cullin, N-terminal
Occurring in:
  1. Cullin-3
IPR016159
Domain description: Cullin repeat-like-containing domain superfamily
Occurring in:
  1. Cullin-3
IPR045093
Domain description: Cullin
Occurring in:
  1. Cullin-3
IPR011705
Domain description: BTB/Kelch-associated
Occurring in:
  1. Kelch-like protein 11
IPR013785
Domain description: Aldolase-type TIM barrel
Occurring in:
  1. Kelch-like protein 11

Structure domains

CATH CATH domains
1.20.1310.10
Class: Mainly Alpha
Architecture: Up-down Bundle
Topology: 5 helical Cullin repeat like
Homology: Cullin Repeats
Occurring in:
  1. Cullin-3
The deposited structure of PDB entry 4ap2 contains 3 copies of CATH domain 1.20.1310.10 (5 helical Cullin repeat like) in Cullin-3. Showing 3 copies in chain B.
1.25.40.420
Class: Mainly Alpha
Architecture: Alpha Horseshoe
Topology: Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat
Homology: Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat
Occurring in:
  1. Kelch-like protein 11
The deposited structure of PDB entry 4ap2 contains 1 copy of CATH domain 1.25.40.420 (Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat) in Kelch-like protein 11. Showing 1 copy in chain A.
3.30.710.10
Class: Alpha Beta
Architecture: 2-Layer Sandwich
Topology: Potassium Channel Kv1.1; Chain A
Homology: Potassium Channel Kv1.1; Chain A
Occurring in:
  1. Kelch-like protein 11
The deposited structure of PDB entry 4ap2 contains 1 copy of CATH domain 3.30.710.10 (Potassium Channel Kv1.1; Chain A) in Kelch-like protein 11. Showing 1 copy in chain A.

Quick links