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Mus musculus Acetylcholinesterase in complex with (S)-C5685 at 2.25 A resolution.

X-ray diffraction
2.25Å resolution
PDB entry 4arb coloured by chain, front view.
PDB entry 4arb coloured by chain, side view.
PDB entry 4arb coloured by chain, top view.
Source organism: Mus musculus
Assembly composition:
homo dimer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Acetylcholinesterase
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Multimeric state: homo dimer
Accessible surface area: 37627.17 Å2
Buried surface area: 4928.01 Å2
Dissociation area: 1,342.54 Å2
Dissociation energy (ΔGdiss): -8.4 kcal/mol
Dissociation entropy (TΔSdiss): 14.6 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-149441

Macromolecules

Acetylcholinesterase
Chains: A, B
Length: 548 amino acids
Theoretical weight: 60.23 KDa
Source organism: Mus musculus
Expression system: Homo sapiens
UniProt:
  • Canonical: P21836 (Residues: 32-574; Coverage: 93%)
Gene name: Ache
Pfam: Carboxylesterase family
InterPro:
CATH: alpha/beta hydrolase
Acetylcholinesterase in PDB entry 4arb, assembly 1, front view.
Acetylcholinesterase in PDB entry 4arb, assembly 1, side view.
Acetylcholinesterase in PDB entry 4arb, assembly 1, top view.
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