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Structure of a complex between CCPs 6 and 7 of Human Complement Factor H and Neisseria meningitidis FHbp Variant 3 P106A mutant

X-ray diffraction
3Å resolution
PDB entry 4aym coloured by chain, front view.
PDB entry 4aym coloured by chain, side view.
PDB entry 4aym coloured by chain, top view.
Source organisms:
Assemblies composition:
hetero dimer (preferred)
monomeric
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Lipoprotein GNA1870 and Complement factor H
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Multimeric state: hetero dimer
Accessible surface area: 16883.56 Å2
Buried surface area: 3089.07 Å2
Dissociation area: 1,544.54 Å2
Dissociation energy (ΔGdiss): 10.76 kcal/mol
Dissociation entropy (TΔSdiss): 12.19 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-140216
Assembly 2
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Assembly Name: Lipoprotein GNA1870 and Complement factor H
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Multimeric state: hetero dimer
Accessible surface area: 16805.14 Å2
Buried surface area: 3190.7 Å2
Dissociation area: 1,595.35 Å2
Dissociation energy (ΔGdiss): 9.58 kcal/mol
Dissociation entropy (TΔSdiss): 12.23 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-140216
Assembly 3
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Assembly Name: Complement factor H
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Multimeric state: monomeric
Accessible surface area: 7636.82 Å2
Buried surface area: 0.0 Å2
Dissociation area: 0 Å2
Dissociation energy (ΔGdiss): 0 kcal/mol
Dissociation entropy (TΔSdiss): 0 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-140213
Assembly 4
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Assembly Name: Complement factor H
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Multimeric state: monomeric
Accessible surface area: 7605.71 Å2
Buried surface area: 0.0 Å2
Dissociation area: 0 Å2
Dissociation energy (ΔGdiss): 0 kcal/mol
Dissociation entropy (TΔSdiss): 0 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-140213

Macromolecules

Complement factor H
Chains: A, B, E, F
Length: 125 amino acids
Theoretical weight: 14.41 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli B
UniProt:
  • Canonical: P08603 (Residues: 321-443; Coverage: 10%)
Gene names: CFH, HF, HF1, HF2
Pfam: Sushi repeat (SCR repeat)
InterPro:
CATH: Complement Module, domain 1
Complement factor H in PDB entry 4aym, assembly 1, front view.
Complement factor H in PDB entry 4aym, assembly 1, side view.
Complement factor H in PDB entry 4aym, assembly 1, top view.
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Lipoprotein GNA1870
Chains: C, D
Length: 270 amino acids
Theoretical weight: 29.49 KDa
Source organism: Neisseria meningitidis MC58
Expression system: Escherichia coli B
UniProt:
  • Canonical: Q19KF7 (Residues: 32-281; Coverage: 95%)
Gene name: gna1870
Pfam:
InterPro:
CATH:
Lipoprotein GNA1870 in PDB entry 4aym, assembly 1, front view.
Lipoprotein GNA1870 in PDB entry 4aym, assembly 1, side view.
Lipoprotein GNA1870 in PDB entry 4aym, assembly 1, top view.
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