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Crystal structure of oxidized Shewanella Yellow Enzyme 4 (SYE4)

Source organism: Shewanella oneidensis MR-1
Biochemical function: riboflavin reductase (NADPH) activity
Biological process: not assigned
Cellular component: cytosol

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EC 1.5.1.30: Flavin reductase (NADPH)

Reaction catalysed:
Reduced riboflavin + NADP(+) = riboflavin + NADPH
Systematic name:
Reduced-riboflavin:NADP(+) oxidoreductase
Alternative Name(s):
  • FMN reductase (NADPH)
  • Flavin mononucleotide reductase
  • Flavine mononucleotide reductase
  • NADPH dehydrogenase (flavin)
  • NADPH(2) dehydrogenase (flavin)
  • NADPH(2):riboflavin oxidoreductase
  • NADPH-FMN reductase
  • NADPH-dependent FMN reductase
  • NADPH-flavin reductase
  • NADPH-specific FMN reductase
  • NADPH:flavin oxidoreductase
  • NADPH:riboflavin oxidoreductase
  • Riboflavin mononucleotide (reduced nicotinamide adenine dinucleotide phosphate) reductase
  • Riboflavin mononucleotide reductase
  • Riboflavine mononucleotide reductase

GO terms

Biochemical function:
Biological process:
  • not assigned
Cellular component:

Sequence family

Pfam Protein family (Pfam)
PF00724
Domain description: NADH:flavin oxidoreductase / NADH oxidase family
Occurring in:
  1. NADH:flavin oxidoreductase/NADH oxidase N-terminal domain-containing protein
The deposited structure of PDB entry 4b5n contains 1 copy of Pfam domain PF00724 (NADH:flavin oxidoreductase / NADH oxidase family) in NADH:flavin oxidoreductase/NADH oxidase N-terminal domain-containing protein. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR001155
Domain description: NADH:flavin oxidoreductase/NADH oxidase, N-terminal
Occurring in:
  1. NADH:flavin oxidoreductase/NADH oxidase N-terminal domain-containing protein
IPR045247
Domain description: Oxidoreductase Oye-like
Occurring in:
  1. NADH:flavin oxidoreductase/NADH oxidase N-terminal domain-containing protein
IPR013785
Domain description: Aldolase-type TIM barrel
Occurring in:
  1. NADH:flavin oxidoreductase/NADH oxidase N-terminal domain-containing protein

Structure domain

CATH CATH domain
3.20.20.70
Class: Alpha Beta
Architecture: Alpha-Beta Barrel
Topology: TIM Barrel
Homology: Aldolase class I
Occurring in:
  1. NADH:flavin oxidoreductase/NADH oxidase N-terminal domain-containing protein
The deposited structure of PDB entry 4b5n contains 1 copy of CATH domain 3.20.20.70 (TIM Barrel) in NADH:flavin oxidoreductase/NADH oxidase N-terminal domain-containing protein. Showing 1 copy in chain A.

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