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The third member of the eIF4E family represses gene expression via a novel mode of recognition of the methyl-7 guanosine cap moiety

Solution NMR
PDB entry 4b6v coloured by chain, ensemble of 10 models, front view.
PDB entry 4b6v coloured by chain, ensemble of 10 models, side view.
PDB entry 4b6v coloured by chain, ensemble of 10 models, top view.
Source organism: Mus musculus
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Eukaryotic translation initiation factor 4E type 3
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Multimeric state: monomeric
Accessible surface area: 13550.9 Å2
Buried surface area: 0.0 Å2
Dissociation area: 0 Å2
Dissociation energy (ΔGdiss): 0 kcal/mol
Dissociation entropy (TΔSdiss): 0 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-190083

Macromolecules

Eukaryotic translation initiation factor 4E type 3
Chain: A
Length: 207 amino acids
Theoretical weight: 22.86 KDa
Source organism: Mus musculus
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q9DBB5 (Residues: 1-207; Coverage: 100%)
Gene name: Eif4e3
Pfam: Eukaryotic initiation factor 4E
InterPro:
CATH: RNA Cap, Translation Initiation Factor Eif4e
Eukaryotic translation initiation factor 4E type 3 in PDB entry 4b6v, assembly 1, front view.
Eukaryotic translation initiation factor 4E type 3 in PDB entry 4b6v, assembly 1, side view.
Eukaryotic translation initiation factor 4E type 3 in PDB entry 4b6v, assembly 1, top view.
PDBe-KB: UniProt Coverage View: Q9DBB5  
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