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H1N1 2009 Pandemic Influenza Virus: Resistance of the I223R Neuraminidase Mutant Explained by Kinetic and Structural Analysis

X-ray diffraction
2.417Å resolution
PDB entry 4b7j coloured by chain, front view.
PDB entry 4b7j coloured by chain, side view.
PDB entry 4b7j coloured by chain, top view.
Source organism: Influenza A virus
Assembly composition:
homo tetramer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Neuraminidase
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Multimeric state: homo tetramer
Accessible surface area: 45279.93 Å2
Buried surface area: 17544.02 Å2
Dissociation area: 6,486.96 Å2
Dissociation energy (ΔGdiss): 52.16 kcal/mol
Dissociation entropy (TΔSdiss): 43.93 kcal/mol
Symmetry number: 4
PDBe Complex ID: PDB-CPX-123733

Macromolecules

Neuraminidase
Chain: A
Length: 469 amino acids
Theoretical weight: 51.7 KDa
Source organism: Influenza A virus
Expression system: Gallus gallus
UniProt:
  • Canonical: F8UU09 (Residues: 1-469; Coverage: 100%)
Gene name: NA
Pfam: Neuraminidase
InterPro:
CATH: Neuraminidase
Neuraminidase in PDB entry 4b7j, assembly 1, front view.
Neuraminidase in PDB entry 4b7j, assembly 1, side view.
Neuraminidase in PDB entry 4b7j, assembly 1, top view.
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