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Crystal structure of 3-oxoacyl-(acyl-carrier-protein) reductase (FabG) from Pseudomonas aeruginosa in complex with 1-(1-ethylbenzimidazol-2- yl)-3-(2-methoxyphenyl)urea at 1.9A resolution

X-ray diffraction
1.9Å resolution
PDB entry 4bo2 coloured by chain, front view.
PDB entry 4bo2 coloured by chain, side view.
PDB entry 4bo2 coloured by chain, top view.
Source organism: Pseudomonas aeruginosa PAO1
Assembly composition:
homo tetramer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: 3-oxoacyl-[acyl-carrier-protein] reductase FabG
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Multimeric state: homo tetramer
Accessible surface area: 37481.57 Å2
Buried surface area: 10260.65 Å2
Dissociation area: 2,351.76 Å2
Dissociation energy (ΔGdiss): 10.2 kcal/mol
Dissociation entropy (TΔSdiss): 14.44 kcal/mol
Symmetry number: 4
PDBe Complex ID: PDB-CPX-129496

Macromolecules

3-oxoacyl-[acyl-carrier-protein] reductase FabG
Chains: A, B, C, D
Length: 269 amino acids
Theoretical weight: 28.17 KDa
Source organism: Pseudomonas aeruginosa PAO1
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: O54438 (Residues: 1-247; Coverage: 100%)
Gene names: PA2967, fabG
Pfam: Enoyl-(Acyl carrier protein) reductase
InterPro:
CATH: NAD(P)-binding Rossmann-like Domain
3-oxoacyl-[acyl-carrier-protein] reductase FabG in PDB entry 4bo2, assembly 1, front view.
3-oxoacyl-[acyl-carrier-protein] reductase FabG in PDB entry 4bo2, assembly 1, side view.
3-oxoacyl-[acyl-carrier-protein] reductase FabG in PDB entry 4bo2, assembly 1, top view.
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