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Structure of mitochondrial RNA polymerase elongation complex

X-ray diffraction
2.65Å resolution
PDB entry 4boc coloured by chain, front view.
PDB entry 4boc coloured by chain, side view.
PDB entry 4boc coloured by chain, top view.
Source organisms:
Assembly composition:
hetero octamer (preferred)
Entry contents: 1 distinct polypeptide molecule
2 distinct DNA molecules
1 distinct RNA molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: DNA-directed RNA polymerase, mitochondrial and RNA and DNA
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Multimeric state: hetero octamer
Accessible surface area: 100199.07 Å2
Buried surface area: 19769.66 Å2
Dissociation area: 1,956.87 Å2
Dissociation energy (ΔGdiss): 0.13 kcal/mol
Dissociation entropy (TΔSdiss): 16.8 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-117261

Macromolecules

DNA-directed RNA polymerase, mitochondrial
Chain: A
Length: 1088 amino acids
Theoretical weight: 123.38 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O00411 (Residues: 151-1230; Coverage: 88%)
Gene name: POLRMT
Pfam:
InterPro:
DNA-directed RNA polymerase, mitochondrial in PDB entry 4boc, assembly 1, front view.
DNA-directed RNA polymerase, mitochondrial in PDB entry 4boc, assembly 1, side view.
DNA-directed RNA polymerase, mitochondrial in PDB entry 4boc, assembly 1, top view.
PDBe-KB: UniProt Coverage View: O00411  
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DNA chain N
Name: 5'-D(*CP*AP*TP*GP*GP*GP*GP*TP*AP*AP*TP*TP*AP*TP *TP*TP*CP*GP*AP*CP*GP*CP*CP*AP*GP*AP*CP*G)-3'
Representative chains: N
Source organism: synthetic construct [32630]
Expression system: Not provided
Length: 28 nucleotides
Theoretical weight: 8.65 KDa
5'-D(*CP*AP*TP*GP*GP*GP*GP*TP*AP*AP*TP*TP*AP*TP *TP*TP*CP*GP*AP*CP*GP*CP*CP*AP*GP*AP*CP*G)-3' in PDB entry 4boc, assembly 1, front view.
5'-D(*CP*AP*TP*GP*GP*GP*GP*TP*AP*AP*TP*TP*AP*TP *TP*TP*CP*GP*AP*CP*GP*CP*CP*AP*GP*AP*CP*G)-3' in PDB entry 4boc, assembly 1, side view.
5'-D(*CP*AP*TP*GP*GP*GP*GP*TP*AP*AP*TP*TP*AP*TP *TP*TP*CP*GP*AP*CP*GP*CP*CP*AP*GP*AP*CP*G)-3' in PDB entry 4boc, assembly 1, top view.
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DNA chain T
Name: 5'-D(*CP*GP*TP*CP*TP*GP*GP*CP*GP*TP*GP*CP*GP*CP *GP*CP*CP*GP*CP*TP*AP*CP*CP*CP*CP*AP*TP*G)-3'
Representative chains: T
Source organism: synthetic construct [32630]
Expression system: Not provided
Length: 28 nucleotides
Theoretical weight: 8.54 KDa
5'-D(*CP*GP*TP*CP*TP*GP*GP*CP*GP*TP*GP*CP*GP*CP *GP*CP*CP*GP*CP*TP*AP*CP*CP*CP*CP*AP*TP*G)-3' in PDB entry 4boc, assembly 1, front view.
5'-D(*CP*GP*TP*CP*TP*GP*GP*CP*GP*TP*GP*CP*GP*CP *GP*CP*CP*GP*CP*TP*AP*CP*CP*CP*CP*AP*TP*G)-3' in PDB entry 4boc, assembly 1, side view.
5'-D(*CP*GP*TP*CP*TP*GP*GP*CP*GP*TP*GP*CP*GP*CP *GP*CP*CP*GP*CP*TP*AP*CP*CP*CP*CP*AP*TP*G)-3' in PDB entry 4boc, assembly 1, top view.
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RNA chain R
Name: 5'-R(*AP*GP*UP*CP*UP*GP*CP*GP*GP*CP*GP*CP*GP*CP)-3'
Representative chains: R
Source organism: synthetic construct [32630]
Expression system: Not provided
Length: 14 nucleotides
Theoretical weight: 4.49 KDa
5'-R(*AP*GP*UP*CP*UP*GP*CP*GP*GP*CP*GP*CP*GP*CP)-3' in PDB entry 4boc, assembly 1, front view.
5'-R(*AP*GP*UP*CP*UP*GP*CP*GP*GP*CP*GP*CP*GP*CP)-3' in PDB entry 4boc, assembly 1, side view.
5'-R(*AP*GP*UP*CP*UP*GP*CP*GP*GP*CP*GP*CP*GP*CP)-3' in PDB entry 4boc, assembly 1, top view.
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