› › Structure analysis

Crystal Structure of High-Affinity von Willebrand Factor A1 domain with Disulfide Mutation in Complex with High Affinity GPIb alpha

X-ray diffraction
2.8Å resolution
PDB entry 4c2b coloured by chain, front view.
PDB entry 4c2b coloured by chain, side view.
PDB entry 4c2b coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero dimer (preferred)
Entry contents: 2 distinct polypeptide molecules

Quick links

Assemblies

Assembly 1
Download    3D Visualisation
Assembly Name: von Willebrand factor and Glycocalicin
hide full assembly name
Multimeric state: hetero dimer
Accessible surface area: 21192.21 Å2
Buried surface area: 2334.88 Å2
Dissociation area: 910.37 Å2
Dissociation energy (ΔGdiss): -2.08 kcal/mol
Dissociation entropy (TΔSdiss): 12.62 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-137564
Assembly 2
Download    3D Visualisation
Assembly Name: von Willebrand factor and Glycocalicin
hide full assembly name
Multimeric state: hetero dimer
Accessible surface area: 20929.19 Å2
Buried surface area: 2368.91 Å2
Dissociation area: 1,008.55 Å2
Dissociation energy (ΔGdiss): -3.98 kcal/mol
Dissociation entropy (TΔSdiss): 12.62 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-137564
Assembly 3
Download    3D Visualisation
Assembly Name: von Willebrand factor and Glycocalicin
hide full assembly name
Multimeric state: hetero dimer
Accessible surface area: 20595.34 Å2
Buried surface area: 2265.08 Å2
Dissociation area: 994.35 Å2
Dissociation energy (ΔGdiss): -3.99 kcal/mol
Dissociation entropy (TΔSdiss): 12.62 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-137564
Assembly 4 (preferred)
Download    3D Visualisation
Assembly Name: von Willebrand factor and Glycocalicin
hide full assembly name
Multimeric state: hetero dimer
Accessible surface area: 20670.35 Å2
Buried surface area: 2907.64 Å2
Dissociation area: 1,036.88 Å2
Dissociation energy (ΔGdiss): -2.76 kcal/mol
Dissociation entropy (TΔSdiss): 12.63 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-137564

Macromolecules

von Willebrand factor
Chains: A, C, E, G
Length: 215 amino acids
Theoretical weight: 24.71 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P04275 (Residues: 1264-1471; Coverage: 8%)
Gene names: F8VWF, VWF
Pfam: von Willebrand factor type A domain
InterPro:
CATH: von Willebrand factor, type A domain
von Willebrand factor in PDB entry 4c2b, assembly 4, front view.
von Willebrand factor in PDB entry 4c2b, assembly 4, side view.
von Willebrand factor in PDB entry 4c2b, assembly 4, top view.
Molecule details ›

Search similar proteins

Glycocalicin
Chains: B, D, F, H
Length: 291 amino acids
Theoretical weight: 32.49 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P07359 (Residues: 17-306; Coverage: 46%)
Gene name: GP1BA
Pfam:
InterPro:
CATH: Ribonuclease Inhibitor
Glycocalicin in PDB entry 4c2b, assembly 4, front view.
Glycocalicin in PDB entry 4c2b, assembly 4, side view.
Glycocalicin in PDB entry 4c2b, assembly 4, top view.
Molecule details ›

Search similar proteins

Quick links