EC 3.4.25.1: Proteasome endopeptidase complex
Reaction catalysed:
Cleavage of peptide bonds with very broad specificity.
Alternative Name(s):
- 26S protease
- Alkaline protease
- Ingensin
- Large multicatalytic protease
- Lens neutral proteinase
- MCP
- Macropain
- Multicatalytic endopeptidase complex
- Multicatalytic proteinase
- Multicatalytic proteinase (complex)
- Prosome
- Proteasome
- Proteasome organelle
- Tricorn protease
- Tricorn proteinase
EC 3.4.19.12: Ubiquitinyl hydrolase 1
Reaction catalysed:
Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).
Systematic name:
-
Alternative Name(s):
- Ubiquitin C-terminal hydrolase
- Ubiquitin carboxyl-terminal hydrolase
- Ubiquitin thiolesterase
- Yeast ubiquitin hydrolase
GO terms
Biochemical function:
Biological process:
Cellular component:
Sequence families
Protein families (Pfam)
PF00227
Domain description:
Proteasome subunit
Occurring in:
Occurring in:
- Proteasome subunit beta type-1
- Proteasome subunit beta type-2
- Proteasome subunit beta type-3
- Proteasome subunit beta type-4
- Proteasome subunit beta type-5
- Proteasome subunit beta type-6
- Proteasome subunit beta type-7
- Proteasome subunit alpha type-1
- Proteasome subunit alpha type-2
- Proteasome subunit alpha type-3
- Proteasome subunit alpha type-4
- Proteasome subunit alpha type-5
- Proteasome subunit alpha type-6
- Probable proteasome subunit alpha type-7
![The deposited structure of PDB entry <span class='highlight'>4cr3</span> contains 1 copy of Pfam domain <span class='highlight'>PF00227 (Proteasome subunit)</span> in <span class='highlight'>Proteasome subunit beta type-1</span>. Showing 1 copy in chain <span class='highlight'>A [auth 1]</span>. The deposited structure of PDB entry 4cr3 contains 1 copy of Pfam domain PF00227 (Proteasome subunit) in Proteasome subunit beta type-1. Showing 1 copy in chain A [auth 1].](https://www.ebi.ac.uk/pdbe/static/entry/4cr3_1_1_Pfam_PF00227_image-200x200.png)
![The deposited structure of PDB entry <span class='highlight'>4cr3</span> contains 1 copy of Pfam domain <span class='highlight'>PF00227 (Proteasome subunit)</span> in <span class='highlight'>Proteasome subunit beta type-2</span>. Showing 1 copy in chain <span class='highlight'>B [auth 2]</span>. The deposited structure of PDB entry 4cr3 contains 1 copy of Pfam domain PF00227 (Proteasome subunit) in Proteasome subunit beta type-2. Showing 1 copy in chain B [auth 2].](https://www.ebi.ac.uk/pdbe/static/entry/4cr3_2_2_Pfam_PF00227_image-200x200.png)
![The deposited structure of PDB entry <span class='highlight'>4cr3</span> contains 1 copy of Pfam domain <span class='highlight'>PF00227 (Proteasome subunit)</span> in <span class='highlight'>Proteasome subunit beta type-3</span>. Showing 1 copy in chain <span class='highlight'>C [auth 3]</span>. The deposited structure of PDB entry 4cr3 contains 1 copy of Pfam domain PF00227 (Proteasome subunit) in Proteasome subunit beta type-3. Showing 1 copy in chain C [auth 3].](https://www.ebi.ac.uk/pdbe/static/entry/4cr3_3_3_Pfam_PF00227_image-200x200.png)
![The deposited structure of PDB entry <span class='highlight'>4cr3</span> contains 1 copy of Pfam domain <span class='highlight'>PF00227 (Proteasome subunit)</span> in <span class='highlight'>Proteasome subunit beta type-4</span>. Showing 1 copy in chain <span class='highlight'>D [auth 4]</span>. The deposited structure of PDB entry 4cr3 contains 1 copy of Pfam domain PF00227 (Proteasome subunit) in Proteasome subunit beta type-4. Showing 1 copy in chain D [auth 4].](https://www.ebi.ac.uk/pdbe/static/entry/4cr3_4_4_Pfam_PF00227_image-200x200.png)
![The deposited structure of PDB entry <span class='highlight'>4cr3</span> contains 1 copy of Pfam domain <span class='highlight'>PF00227 (Proteasome subunit)</span> in <span class='highlight'>Proteasome subunit beta type-5</span>. Showing 1 copy in chain <span class='highlight'>E [auth 5]</span>. The deposited structure of PDB entry 4cr3 contains 1 copy of Pfam domain PF00227 (Proteasome subunit) in Proteasome subunit beta type-5. Showing 1 copy in chain E [auth 5].](https://www.ebi.ac.uk/pdbe/static/entry/4cr3_5_5_Pfam_PF00227_image-200x200.png)
![The deposited structure of PDB entry <span class='highlight'>4cr3</span> contains 1 copy of Pfam domain <span class='highlight'>PF00227 (Proteasome subunit)</span> in <span class='highlight'>Proteasome subunit beta type-6</span>. Showing 1 copy in chain <span class='highlight'>F [auth 6]</span>. The deposited structure of PDB entry 4cr3 contains 1 copy of Pfam domain PF00227 (Proteasome subunit) in Proteasome subunit beta type-6. Showing 1 copy in chain F [auth 6].](https://www.ebi.ac.uk/pdbe/static/entry/4cr3_6_6_Pfam_PF00227_image-200x200.png)
![The deposited structure of PDB entry <span class='highlight'>4cr3</span> contains 1 copy of Pfam domain <span class='highlight'>PF00227 (Proteasome subunit)</span> in <span class='highlight'>Proteasome subunit beta type-7</span>. Showing 1 copy in chain <span class='highlight'>G [auth 7]</span>. The deposited structure of PDB entry 4cr3 contains 1 copy of Pfam domain PF00227 (Proteasome subunit) in Proteasome subunit beta type-7. Showing 1 copy in chain G [auth 7].](https://www.ebi.ac.uk/pdbe/static/entry/4cr3_7_7_Pfam_PF00227_image-200x200.png)
![The deposited structure of PDB entry <span class='highlight'>4cr3</span> contains 1 copy of Pfam domain <span class='highlight'>PF00227 (Proteasome subunit)</span> in <span class='highlight'>Proteasome subunit alpha type-1</span>. Showing 1 copy in chain <span class='highlight'>H [auth A]</span>. The deposited structure of PDB entry 4cr3 contains 1 copy of Pfam domain PF00227 (Proteasome subunit) in Proteasome subunit alpha type-1. Showing 1 copy in chain H [auth A].](https://www.ebi.ac.uk/pdbe/static/entry/4cr3_8_A_Pfam_PF00227_image-200x200.png)
![The deposited structure of PDB entry <span class='highlight'>4cr3</span> contains 1 copy of Pfam domain <span class='highlight'>PF00227 (Proteasome subunit)</span> in <span class='highlight'>Proteasome subunit alpha type-2</span>. Showing 1 copy in chain <span class='highlight'>I [auth B]</span>. The deposited structure of PDB entry 4cr3 contains 1 copy of Pfam domain PF00227 (Proteasome subunit) in Proteasome subunit alpha type-2. Showing 1 copy in chain I [auth B].](https://www.ebi.ac.uk/pdbe/static/entry/4cr3_9_B_Pfam_PF00227_image-200x200.png)
![The deposited structure of PDB entry <span class='highlight'>4cr3</span> contains 1 copy of Pfam domain <span class='highlight'>PF00227 (Proteasome subunit)</span> in <span class='highlight'>Proteasome subunit alpha type-3</span>. Showing 1 copy in chain <span class='highlight'>J [auth C]</span>. The deposited structure of PDB entry 4cr3 contains 1 copy of Pfam domain PF00227 (Proteasome subunit) in Proteasome subunit alpha type-3. Showing 1 copy in chain J [auth C].](https://www.ebi.ac.uk/pdbe/static/entry/4cr3_10_C_Pfam_PF00227_image-200x200.png)
![The deposited structure of PDB entry <span class='highlight'>4cr3</span> contains 1 copy of Pfam domain <span class='highlight'>PF00227 (Proteasome subunit)</span> in <span class='highlight'>Proteasome subunit alpha type-4</span>. Showing 1 copy in chain <span class='highlight'>K [auth D]</span>. The deposited structure of PDB entry 4cr3 contains 1 copy of Pfam domain PF00227 (Proteasome subunit) in Proteasome subunit alpha type-4. Showing 1 copy in chain K [auth D].](https://www.ebi.ac.uk/pdbe/static/entry/4cr3_11_D_Pfam_PF00227_image-200x200.png)
![The deposited structure of PDB entry <span class='highlight'>4cr3</span> contains 1 copy of Pfam domain <span class='highlight'>PF00227 (Proteasome subunit)</span> in <span class='highlight'>Proteasome subunit alpha type-5</span>. Showing 1 copy in chain <span class='highlight'>L [auth E]</span>. The deposited structure of PDB entry 4cr3 contains 1 copy of Pfam domain PF00227 (Proteasome subunit) in Proteasome subunit alpha type-5. Showing 1 copy in chain L [auth E].](https://www.ebi.ac.uk/pdbe/static/entry/4cr3_12_E_Pfam_PF00227_image-200x200.png)
![The deposited structure of PDB entry <span class='highlight'>4cr3</span> contains 1 copy of Pfam domain <span class='highlight'>PF00227 (Proteasome subunit)</span> in <span class='highlight'>Proteasome subunit alpha type-6</span>. Showing 1 copy in chain <span class='highlight'>M [auth F]</span>. The deposited structure of PDB entry 4cr3 contains 1 copy of Pfam domain PF00227 (Proteasome subunit) in Proteasome subunit alpha type-6. Showing 1 copy in chain M [auth F].](https://www.ebi.ac.uk/pdbe/static/entry/4cr3_13_F_Pfam_PF00227_image-200x200.png)
![The deposited structure of PDB entry <span class='highlight'>4cr3</span> contains 1 copy of Pfam domain <span class='highlight'>PF00227 (Proteasome subunit)</span> in <span class='highlight'>Probable proteasome subunit alpha type-7</span>. Showing 1 copy in chain <span class='highlight'>N [auth G]</span>. The deposited structure of PDB entry 4cr3 contains 1 copy of Pfam domain PF00227 (Proteasome subunit) in Probable proteasome subunit alpha type-7. Showing 1 copy in chain N [auth G].](https://www.ebi.ac.uk/pdbe/static/entry/4cr3_14_G_Pfam_PF00227_image-200x200.png)
PF00004
Domain description:
ATPase family associated with various cellular activities (AAA)
Occurring in:
Occurring in:
![The deposited structure of PDB entry <span class='highlight'>4cr3</span> contains 1 copy of Pfam domain <span class='highlight'>PF00004 (ATPase family associated with various cellular activities (AAA))</span> in <span class='highlight'>26S proteasome regulatory subunit 7 homolog</span>. Showing 1 copy in chain <span class='highlight'>O [auth H]</span>. The deposited structure of PDB entry 4cr3 contains 1 copy of Pfam domain PF00004 (ATPase family associated with various cellular activities (AAA)) in 26S proteasome regulatory subunit 7 homolog. Showing 1 copy in chain O [auth H].](https://www.ebi.ac.uk/pdbe/static/entry/4cr3_15_H_Pfam_PF00004_image-200x200.png)
![The deposited structure of PDB entry <span class='highlight'>4cr3</span> contains 1 copy of Pfam domain <span class='highlight'>PF00004 (ATPase family associated with various cellular activities (AAA))</span> in <span class='highlight'>26S proteasome regulatory subunit 4 homolog</span>. Showing 1 copy in chain <span class='highlight'>P [auth I]</span>. The deposited structure of PDB entry 4cr3 contains 1 copy of Pfam domain PF00004 (ATPase family associated with various cellular activities (AAA)) in 26S proteasome regulatory subunit 4 homolog. Showing 1 copy in chain P [auth I].](https://www.ebi.ac.uk/pdbe/static/entry/4cr3_16_I_Pfam_PF00004_image-200x200.png)
![The deposited structure of PDB entry <span class='highlight'>4cr3</span> contains 1 copy of Pfam domain <span class='highlight'>PF00004 (ATPase family associated with various cellular activities (AAA))</span> in <span class='highlight'>26S proteasome regulatory subunit 8 homolog</span>. Showing 1 copy in chain <span class='highlight'>Q [auth J]</span>. The deposited structure of PDB entry 4cr3 contains 1 copy of Pfam domain PF00004 (ATPase family associated with various cellular activities (AAA)) in 26S proteasome regulatory subunit 8 homolog. Showing 1 copy in chain Q [auth J].](https://www.ebi.ac.uk/pdbe/static/entry/4cr3_17_J_Pfam_PF00004_image-200x200.png)
![The deposited structure of PDB entry <span class='highlight'>4cr3</span> contains 1 copy of Pfam domain <span class='highlight'>PF00004 (ATPase family associated with various cellular activities (AAA))</span> in <span class='highlight'>26S proteasome regulatory subunit 6B homolog</span>. Showing 1 copy in chain <span class='highlight'>R [auth K]</span>. The deposited structure of PDB entry 4cr3 contains 1 copy of Pfam domain PF00004 (ATPase family associated with various cellular activities (AAA)) in 26S proteasome regulatory subunit 6B homolog. Showing 1 copy in chain R [auth K].](https://www.ebi.ac.uk/pdbe/static/entry/4cr3_18_K_Pfam_PF00004_image-200x200.png)
![The deposited structure of PDB entry <span class='highlight'>4cr3</span> contains 1 copy of Pfam domain <span class='highlight'>PF00004 (ATPase family associated with various cellular activities (AAA))</span> in <span class='highlight'>26S proteasome subunit RPT4</span>. Showing 1 copy in chain <span class='highlight'>S [auth L]</span>. The deposited structure of PDB entry 4cr3 contains 1 copy of Pfam domain PF00004 (ATPase family associated with various cellular activities (AAA)) in 26S proteasome subunit RPT4. Showing 1 copy in chain S [auth L].](https://www.ebi.ac.uk/pdbe/static/entry/4cr3_19_L_Pfam_PF00004_image-200x200.png)
![The deposited structure of PDB entry <span class='highlight'>4cr3</span> contains 1 copy of Pfam domain <span class='highlight'>PF00004 (ATPase family associated with various cellular activities (AAA))</span> in <span class='highlight'>26S proteasome regulatory subunit 6A</span>. Showing 1 copy in chain <span class='highlight'>T [auth M]</span>. The deposited structure of PDB entry 4cr3 contains 1 copy of Pfam domain PF00004 (ATPase family associated with various cellular activities (AAA)) in 26S proteasome regulatory subunit 6A. Showing 1 copy in chain T [auth M].](https://www.ebi.ac.uk/pdbe/static/entry/4cr3_20_M_Pfam_PF00004_image-200x200.png)
PF18051
Domain description:
26S proteasome non-ATPase regulatory subunit RPN1 C-terminal
Occurring in:
Occurring in:
![The deposited structure of PDB entry <span class='highlight'>4cr3</span> contains 1 copy of Pfam domain <span class='highlight'>PF18051 (26S proteasome non-ATPase regulatory subunit RPN1 C-terminal)</span> in <span class='highlight'>26S proteasome regulatory subunit RPN1</span>. Showing 1 copy in chain <span class='highlight'>GA [auth Z]</span>. The deposited structure of PDB entry 4cr3 contains 1 copy of Pfam domain PF18051 (26S proteasome non-ATPase regulatory subunit RPN1 C-terminal) in 26S proteasome regulatory subunit RPN1. Showing 1 copy in chain GA [auth Z].](https://www.ebi.ac.uk/pdbe/static/entry/4cr3_33_Z_Pfam_PF18051_image-200x200.png)
PF21154
Domain description:
26S proteasome regulatory subunit RPN7/PSMD6 C-terminal helix
Occurring in:
Occurring in:
![The deposited structure of PDB entry <span class='highlight'>4cr3</span> contains 1 copy of Pfam domain <span class='highlight'>PF21154 (26S proteasome regulatory subunit RPN7/PSMD6 C-terminal helix)</span> in <span class='highlight'>26S proteasome regulatory subunit RPN7</span>. Showing 1 copy in chain <span class='highlight'>Y [auth R]</span>. The deposited structure of PDB entry 4cr3 contains 1 copy of Pfam domain PF21154 (26S proteasome regulatory subunit RPN7/PSMD6 C-terminal helix) in 26S proteasome regulatory subunit RPN7. Showing 1 copy in chain Y [auth R].](https://www.ebi.ac.uk/pdbe/static/entry/4cr3_25_R_Pfam_PF21154_image-200x200.png)
InterPro annotations
IPR029055
Domain description:
Nucleophile aminohydrolases, N-terminal
Occurring in:
Occurring in:
- Proteasome subunit beta type-1
- Proteasome subunit beta type-2
- Proteasome subunit beta type-3
- Proteasome subunit beta type-4
- Proteasome subunit beta type-5
- Proteasome subunit beta type-6
- Proteasome subunit beta type-7
- Proteasome subunit alpha type-1
- Proteasome subunit alpha type-2
- Proteasome subunit alpha type-3
- Proteasome subunit alpha type-4
- Proteasome subunit alpha type-5
- Proteasome subunit alpha type-6
- Probable proteasome subunit alpha type-7
IPR001353
Domain description:
Proteasome, subunit alpha/beta
Occurring in:
Occurring in:
- Proteasome subunit beta type-1
- Proteasome subunit beta type-2
- Proteasome subunit beta type-3
- Proteasome subunit beta type-4
- Proteasome subunit beta type-5
- Proteasome subunit beta type-6
- Proteasome subunit beta type-7
- Proteasome subunit alpha type-1
- Proteasome subunit alpha type-2
- Proteasome subunit alpha type-3
- Proteasome subunit alpha type-4
- Proteasome subunit alpha type-5
- Proteasome subunit alpha type-6
- Probable proteasome subunit alpha type-7
IPR041433
Domain description:
26S proteasome non-ATPase regulatory subunit RPN1, C-terminal
Occurring in:
Occurring in:
IPR016643
Domain description:
26S proteasome regulatory complex, non-ATPase subcomplex, Rpn1 subunit
Occurring in:
Occurring in:
IPR038633
Domain description:
Proteasomal ubiquitin receptor Rpn13/ADRM1, Pru domain superfamily
Occurring in:
Occurring in:
IPR019585
Domain description:
26S proteasome regulatory subunit Rpn7/COP9 signalosome complex subunit 1
Occurring in:
Occurring in:
IPR040896
Domain description:
26S proteasome regulatory subunit RPN5, C-terminal domain
Occurring in:
Occurring in:
IPR040134
Domain description:
26S Proteasome non-ATPase regulatory subunit 12/COP9 signalosome complex subunit 4
Occurring in:
Occurring in:
IPR016642
Domain description:
26S proteasome regulatory complex, non-ATPase subcomplex, Rpn2/Psmd1 subunit
Occurring in:
Occurring in: