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Cytochrome P450 3A4 bound to an inhibitor

X-ray diffraction
2.25Å resolution
PDB entry 4d75 coloured by chain, front view.
PDB entry 4d75 coloured by chain, side view.
PDB entry 4d75 coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Cytochrome P450 3A4
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Multimeric state: monomeric
Accessible surface area: 20166.26 Å2
Buried surface area: 1252.09 Å2
Dissociation area: 626.05 Å2
Dissociation energy (ΔGdiss): 21.45 kcal/mol
Dissociation entropy (TΔSdiss): 5.88 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-140289

Macromolecules

Cytochrome P450 3A4
Chain: A
Length: 487 amino acids
Theoretical weight: 55.64 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: P08684 (Residues: 23-503; Coverage: 96%)
Gene names: CYP3A3, CYP3A4
Pfam: Cytochrome P450
InterPro:
CATH: Cytochrome P450
Cytochrome P450 3A4 in PDB entry 4d75, assembly 1, front view.
Cytochrome P450 3A4 in PDB entry 4d75, assembly 1, side view.
Cytochrome P450 3A4 in PDB entry 4d75, assembly 1, top view.
PDBe-KB: UniProt Coverage View: P08684  
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