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Structure of Bace-1 (Beta-Secretase) in Complex with (2R)-N-((2S,3R)-1-(benzo[d][1,3]dioxol-5-yl)-3-hydroxy-4-((S)-6'-neopentyl-3',4'-dihydrospiro[cyclobutane-1,2'-pyrano[2,3-b]pyridine]-4'-ylamino)butan-2-yl)-2-methoxypropanamide

X-ray diffraction
2.5Å resolution
PDB entry 4dh6 coloured by chain, front view.
PDB entry 4dh6 coloured by chain, side view.
PDB entry 4dh6 coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Beta-secretase 1
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Multimeric state: monomeric
PDBe Complex ID: PDB-CPX-157541

Macromolecules

Beta-secretase 1
Chain: A
Length: 411 amino acids
Theoretical weight: 45.82 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P56817 (Residues: 43-453; Coverage: 86%)
Gene names: BACE, BACE1, KIAA1149
Pfam: Eukaryotic aspartyl protease
InterPro:
CATH: Acid Proteases
Beta-secretase 1 in PDB entry 4dh6, assembly 1, front view.
Beta-secretase 1 in PDB entry 4dh6, assembly 1, side view.
Beta-secretase 1 in PDB entry 4dh6, assembly 1, top view.
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