Structure analysis

Structure of the hemagglutinin from a highly pathogenic H7N7 influenza virus

X-ray diffraction
2.61Å resolution
Assembly composition:
hetero hexamer (preferred)
Entry contents: 2 distinct polypeptide molecules

Assemblies

Assembly 1 (preferred)
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Multimeric state: hetero hexamer
Accessible surface area: 59253.73 Å2
Buried surface area: 35151.85 Å2
Dissociation area: 6,900.7 Å2
Dissociation energy (ΔGdiss): 48.9 kcal/mol
Dissociation entropy (TΔSdiss): 32.15 kcal/mol
Symmetry number: 3
PDBe Complex ID: PDB-CPX-180463

Macromolecules

Chains: A, C, E
Length: 327 amino acids
Theoretical weight: 35.88 KDa
Source organism: Influenza A virus (A/Netherlands/219/2003(H7N7))
Expression system: Trichoplusia ni
UniProt:
  • Canonical: Q6VMK1 (Residues: 19-341; Coverage: 58%)
Gene name: HA
Pfam: Haemagglutinin
InterPro:
CATH:
PDBe-KB: UniProt Coverage View: Q6VMK1  
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Chains: B, D, F
Length: 177 amino acids
Theoretical weight: 20.43 KDa
Source organism: Influenza A virus (A/Netherlands/219/2003(H7N7))
Expression system: Trichoplusia ni
UniProt:
  • Canonical: Q6VMK1 (Residues: 342-515; Coverage: 31%)
Gene name: HA
Pfam: Haemagglutinin
InterPro:
CATH: Hemagglutinin Ectodomain; Chain B
PDBe-KB: UniProt Coverage View: Q6VMK1  
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