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Crystal structure of the Helicobacter pylori CagA oncoprotein

X-ray diffraction
3.3Å resolution
PDB entry 4dvy coloured by chain, front view.
PDB entry 4dvy coloured by chain, side view.
PDB entry 4dvy coloured by chain, top view.
Source organism: Helicobacter pylori 26695
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Cytotoxicity-associated immunodominant antigen
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Multimeric state: monomeric
Accessible surface area: 38427.76 Å2
Buried surface area: 0.0 Å2
Dissociation area: 0 Å2
Dissociation energy (ΔGdiss): 0 kcal/mol
Dissociation entropy (TΔSdiss): 0 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-157374

Macromolecules

Cytotoxicity-associated immunodominant antigen
Chain: P
Length: 876 amino acids
Theoretical weight: 98.44 KDa
Source organism: Helicobacter pylori 26695
Expression system: Escherichia coli
UniProt:
  • Canonical: P55980 (Residues: 1-876; Coverage: 74%)
Gene names: HP_0547, cag26, cagA, cai
Pfam: CagA protein
InterPro:
CATH:
Cytotoxicity-associated immunodominant antigen in PDB entry 4dvy, assembly 1, front view.
Cytotoxicity-associated immunodominant antigen in PDB entry 4dvy, assembly 1, side view.
Cytotoxicity-associated immunodominant antigen in PDB entry 4dvy, assembly 1, top view.
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