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Crystal structure of kynurenine formamidase conjugated with an inhibitor

X-ray diffraction
1.5Å resolution
PDB entry 4e15 coloured by chain, front view.
PDB entry 4e15 coloured by chain, side view.
PDB entry 4e15 coloured by chain, top view.
Source organism: Drosophila melanogaster
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1
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Assembly Name: Kynurenine formamidase
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Multimeric state: monomeric
Accessible surface area: 12974.31 Å2
Buried surface area: 781.21 Å2
Dissociation area: 96.57 Å2
Dissociation energy (ΔGdiss): -2.95 kcal/mol
Dissociation entropy (TΔSdiss): -0.24 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-194279
Assembly 2 (preferred)
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Assembly Name: Kynurenine formamidase
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Multimeric state: monomeric
Accessible surface area: 13024.05 Å2
Buried surface area: 218.49 Å2
Dissociation area: 109.25 Å2
Dissociation energy (ΔGdiss): -2.44 kcal/mol
Dissociation entropy (TΔSdiss): -0.26 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-194279

Macromolecules

Kynurenine formamidase
Chains: A, B
Length: 303 amino acids
Theoretical weight: 35.37 KDa
Source organism: Drosophila melanogaster
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q9VMC9 (Residues: 1-300; Coverage: 100%)
Gene names: CG9542, KFase
Pfam: alpha/beta hydrolase fold
InterPro:
CATH: alpha/beta hydrolase
Kynurenine formamidase in PDB entry 4e15, assembly 2, front view.
Kynurenine formamidase in PDB entry 4e15, assembly 2, side view.
Kynurenine formamidase in PDB entry 4e15, assembly 2, top view.
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