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Crystal structure of the formin homology 2 domain of FMNL3 bound to actin

X-ray diffraction
3.4Å resolution
PDB entry 4eah coloured by chain, front view.
PDB entry 4eah coloured by chain, side view.
PDB entry 4eah coloured by chain, top view.
Source organisms:
Assembly composition:
hetero tetramer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Formin-like protein 3 and Actin, alpha skeletal muscle
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Multimeric state: hetero tetramer
Accessible surface area: 63051.18 Å2
Buried surface area: 18316.35 Å2
Dissociation area: 3,487.36 Å2
Dissociation energy (ΔGdiss): 0.66 kcal/mol
Dissociation entropy (TΔSdiss): 29.71 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-159318
Assembly 2
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Assembly Name: Formin-like protein 3 and Actin, alpha skeletal muscle
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Multimeric state: hetero tetramer
Accessible surface area: 63071.11 Å2
Buried surface area: 18369.96 Å2
Dissociation area: 3,538.92 Å2
Dissociation energy (ΔGdiss): 1.54 kcal/mol
Dissociation entropy (TΔSdiss): 29.73 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-159318

Macromolecules

Actin, alpha skeletal muscle
Chains: D, F, G, H
Length: 377 amino acids
Theoretical weight: 42.1 KDa
Source organism: Oryctolagus cuniculus
UniProt:
  • Canonical: P68135 (Residues: 1-377; Coverage: 100%)
Gene names: ACTA, ACTA1
Pfam: Actin
InterPro:
CATH:
Actin, alpha skeletal muscle in PDB entry 4eah, assembly 1, front view.
Actin, alpha skeletal muscle in PDB entry 4eah, assembly 1, side view.
Actin, alpha skeletal muscle in PDB entry 4eah, assembly 1, top view.
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Formin-like protein 3
Chains: A, B, C, E
Length: 402 amino acids
Theoretical weight: 46.01 KDa
Source organism: Mus musculus
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: Q6ZPF4 (Residues: 555-954; Coverage: 39%)
Gene names: Fmnl3, Frl2, Kiaa2014
Pfam: Formin Homology 2 Domain
InterPro:
CATH: Formin, FH2 domain
Formin-like protein 3 in PDB entry 4eah, assembly 1, front view.
Formin-like protein 3 in PDB entry 4eah, assembly 1, side view.
Formin-like protein 3 in PDB entry 4eah, assembly 1, top view.
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