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Crystal Structure of Adenylosuccinate Lyase from Francisella tularensis Complexed with AMP and Succinate

Source organism: Francisella tularensis subsp. tularensis SCHU S4
Biochemical function: (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido) succinate lyase (fumarate-forming) activity
Biological process: 'de novo' AMP biosynthetic process
Cellular component: cytosol

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EC 4.3.2.2: Adenylosuccinate lyase

Reaction catalysed:
(S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate = fumarate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide
Systematic name:
N(6)-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming)
Alternative Name(s):
  • 6-N-(1,2-dicarboxyethyl)AMP AMP-lyase
  • Adenylosuccinase
  • Succino AMP-lyase

GO terms

Sequence family

Pfam Protein family (Pfam)
PF00206
Domain description: Lyase
Occurring in:
  1. Adenylosuccinate lyase
The deposited structure of PDB entry 4eei contains 2 copies of Pfam domain PF00206 (Lyase) in Adenylosuccinate lyase. Showing 1 copy in chain B.

InterPro InterPro annotations
IPR000362
Domain description: Fumarate lyase family
Occurring in:
  1. Adenylosuccinate lyase
IPR020557
Domain description: Fumarate lyase, conserved site
Occurring in:
  1. Adenylosuccinate lyase
IPR022761
Domain description: Fumarate lyase, N-terminal
Occurring in:
  1. Adenylosuccinate lyase
IPR008948
Domain description: L-Aspartase-like
Occurring in:
  1. Adenylosuccinate lyase
IPR024083
Domain description: Fumarase/histidase, N-terminal
Occurring in:
  1. Adenylosuccinate lyase
IPR004769
Domain description: Adenylosuccinate lyase
Occurring in:
  1. Adenylosuccinate lyase

Structure domains

CATH CATH domains
1.10.40.30
Class: Mainly Alpha
Architecture: Orthogonal Bundle
Topology: Ribonucleotide Reductase Protein R1; domain 1
Homology: Fumarase/aspartase (C-terminal domain)
Occurring in:
  1. Adenylosuccinate lyase
The deposited structure of PDB entry 4eei contains 2 copies of CATH domain 1.10.40.30 (Ribonucleotide Reductase Protein R1; domain 1) in Adenylosuccinate lyase. Showing 1 copy in chain B.
1.20.200.10
Class: Mainly Alpha
Architecture: Up-down Bundle
Topology: Fumarase C; Chain A, domain 2
Homology: Fumarase/aspartase (Central domain)
Occurring in:
  1. Adenylosuccinate lyase
The deposited structure of PDB entry 4eei contains 2 copies of CATH domain 1.20.200.10 (Fumarase C; Chain A, domain 2) in Adenylosuccinate lyase. Showing 1 copy in chain B.
1.10.275.10
Class: Mainly Alpha
Architecture: Orthogonal Bundle
Topology: Fumarase C; Chain B, domain 1
Homology: Fumarase/aspartase (N-terminal domain)
Occurring in:
  1. Adenylosuccinate lyase
The deposited structure of PDB entry 4eei contains 2 copies of CATH domain 1.10.275.10 (Fumarase C; Chain B, domain 1) in Adenylosuccinate lyase. Showing 1 copy in chain B.

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