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Structure of polymerase-interacting domain of human Rev1 in complex with translesional synthesis polymerase zeta

X-ray diffraction
1.9Å resolution
PDB entry 4ext coloured by chain, front view.
PDB entry 4ext coloured by chain, side view.
PDB entry 4ext coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero trimer (preferred)
Entry contents: 3 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Multimeric state: hetero trimer
Accessible surface area: 16104.26 Å2
Buried surface area: 3693.67 Å2
Dissociation area: 654.55 Å2
Dissociation energy (ΔGdiss): -0.58 kcal/mol
Dissociation entropy (TΔSdiss): 11.3 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-130061
Assembly 2
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Multimeric state: hetero trimer
Accessible surface area: 15860.11 Å2
Buried surface area: 3936.7 Å2
Dissociation area: 785.1 Å2
Dissociation energy (ΔGdiss): 4.67 kcal/mol
Dissociation entropy (TΔSdiss): 11.31 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-130061

Macromolecules

DNA repair protein REV1
Chain: A
Length: 96 amino acids
Theoretical weight: 11.12 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9UBZ9 (Residues: 1156-1251; Coverage: 8%)
Gene names: REV1, REV1L
Pfam: DNA repair protein REV1 C-terminal domain
InterPro:
CATH: DNA repair protein Rev1, C-terminal domain
DNA repair protein REV1 in PDB entry 4ext, assembly 1, front view.
DNA repair protein REV1 in PDB entry 4ext, assembly 1, side view.
DNA repair protein REV1 in PDB entry 4ext, assembly 1, top view.
PDBe-KB: UniProt Coverage View: Q9UBZ9  
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DNA polymerase zeta catalytic subunit
Chain: B
Length: 23 amino acids
Theoretical weight: 2.59 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O60673 (Residues: 1873-1895; Coverage: 1%)
Gene names: POLZ, REV3, REV3L
DNA polymerase zeta catalytic subunit in PDB entry 4ext, assembly 1, front view.
DNA polymerase zeta catalytic subunit in PDB entry 4ext, assembly 1, side view.
DNA polymerase zeta catalytic subunit in PDB entry 4ext, assembly 1, top view.
PDBe-KB: UniProt Coverage View: O60673  
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Mitotic spindle assembly checkpoint protein MAD2B
Chain: C
Length: 204 amino acids
Theoretical weight: 23.62 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9UI95 (Residues: 7-209; Coverage: 96%)
Gene names: MAD2B, MAD2L2, REV7
Pfam: HORMA domain
InterPro:
CATH: HORMA domain
Mitotic spindle assembly checkpoint protein MAD2B in PDB entry 4ext, assembly 1, front view.
Mitotic spindle assembly checkpoint protein MAD2B in PDB entry 4ext, assembly 1, side view.
Mitotic spindle assembly checkpoint protein MAD2B in PDB entry 4ext, assembly 1, top view.
PDBe-KB: UniProt Coverage View: Q9UI95  
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