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Crystal structure of KAP beta2-PY-NLS

X-ray diffraction
2.3Å resolution
PDB entry 4fdd coloured by chain, front view.
PDB entry 4fdd coloured by chain, side view.
PDB entry 4fdd coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero dimer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Transportin-1 and RNA-binding protein FUS
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Multimeric state: hetero dimer
Accessible surface area: 37426.74 Å2
Buried surface area: 2538.7 Å2
Dissociation area: 1,269.35 Å2
Dissociation energy (ΔGdiss): 9.65 kcal/mol
Dissociation entropy (TΔSdiss): 9.42 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-152978

Macromolecules

Transportin-1
Chain: A
Length: 852 amino acids
Theoretical weight: 96.62 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q92973 (Residues: 9-331, 375-898; Coverage: 94%)
Gene names: KPNB2, MIP1, TNPO1, TRN
Pfam:
InterPro:
CATH: Leucine-rich Repeat Variant
Transportin-1 in PDB entry 4fdd, assembly 1, front view.
Transportin-1 in PDB entry 4fdd, assembly 1, side view.
Transportin-1 in PDB entry 4fdd, assembly 1, top view.
PDBe-KB: UniProt Coverage View: Q92973  
1852100200300400500600700800
 
200400600800
UniProt
Q92973
Chains
Domains
Secondary structure
Flexibility predictions
Early folding residue predictions
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RNA-binding protein FUS
Chain: B
Length: 29 amino acids
Theoretical weight: 3.3 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P35637 (Residues: 498-526; Coverage: 6%)
Gene names: FUS, TLS
RNA-binding protein FUS in PDB entry 4fdd, assembly 1, front view.
RNA-binding protein FUS in PDB entry 4fdd, assembly 1, side view.
RNA-binding protein FUS in PDB entry 4fdd, assembly 1, top view.
PDBe-KB: UniProt Coverage View: P35637  
129246810121416182022242628
 
102030RGGGDRGGFGPGKMDSRGEHRQDRRERPY
UniProt
P35637
Chains
Secondary structure
Flexibility predictions
Early folding residue predictions
Interaction interfaces
Molecule details ›

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