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Crystal structure of CASPASE-7 in Complex with allosteric inhibitor

X-ray diffraction
3.79Å resolution
PDB entry 4fea coloured by chain, front view.
PDB entry 4fea coloured by chain, side view.
PDB entry 4fea coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
homo dimer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Caspase-7
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Multimeric state: homo dimer
Accessible surface area: 16272.36 Å2
Buried surface area: 2361.38 Å2
Dissociation area: 1,180.69 Å2
Dissociation energy (ΔGdiss): 6.15 kcal/mol
Dissociation entropy (TΔSdiss): 12.41 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-157233

Macromolecules

Caspase-7 subunit p20
Chains: A, B
Length: 247 amino acids
Theoretical weight: 28.09 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P55210 (Residues: 57-303; Coverage: 82%)
Gene names: CASP7, MCH3
Pfam: Caspase domain
InterPro:
CATH: Rossmann fold
Caspase-7 subunit p20 in PDB entry 4fea, assembly 1, front view.
Caspase-7 subunit p20 in PDB entry 4fea, assembly 1, side view.
Caspase-7 subunit p20 in PDB entry 4fea, assembly 1, top view.
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