Structure analysis

P38a MAP kinase DEF-pocket penta mutant (M194A, L195A, H228A, I229A, Y258A)

X-ray diffraction
1.66Å resolution
Source organism: Homo sapiens
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

Assemblies

Assembly 1 (preferred)
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Multimeric state: monomeric
Accessible surface area: 16482.37 Å2
Buried surface area: 1459.05 Å2
Dissociation area: 395.1 Å2
Dissociation energy (ΔGdiss): -9.89 kcal/mol
Dissociation entropy (TΔSdiss): 4.21 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-172487
    Assembly 1
Confidence : 12%
No. subunits : 1
Symmetry : None

Macromolecules

Chain: A
Length: 367 amino acids
Theoretical weight: 41.94 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q16539 (Residues: 2-360; Coverage: 100%)
Gene names: CSBP, CSBP1, CSBP2, CSPB1, MAPK14, MXI2, SAPK2A
Pfam: Protein kinase domain
InterPro:
CATH:
PDBe-KB: UniProt Coverage View: Q16539  
136750100150200250300350
 
100200300
UniProt
Q16539
Chains
Domains
Secondary structure
Flexibility predictions
Topology annotations
Early folding residue predictions
Ligand binding sites

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