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Crystal Structure of Ca2+/CaM:Kv7.4 (KCNQ4) B helix complex

X-ray diffraction
2.6Å resolution
PDB entry 4gow coloured by chain, front view.
PDB entry 4gow coloured by chain, side view.
PDB entry 4gow coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero dimer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Calmodulin-1 and Potassium voltage-gated channel subfamily KQT member 4
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Multimeric state: hetero dimer
Accessible surface area: 9585.26 Å2
Buried surface area: 3304.73 Å2
Dissociation area: 1,458.44 Å2
Dissociation energy (ΔGdiss): 20.66 kcal/mol
Dissociation entropy (TΔSdiss): 9.63 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-143929

Macromolecules

Calmodulin-1
Chain: D
Length: 144 amino acids
Theoretical weight: 16.33 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P0DP23 (Residues: 4-147; Coverage: 97%)
Gene names: CALM, CALM1, CAM, CAM1
Pfam: EF-hand domain pair
InterPro:
Calmodulin-1 in PDB entry 4gow, assembly 1, front view.
Calmodulin-1 in PDB entry 4gow, assembly 1, side view.
Calmodulin-1 in PDB entry 4gow, assembly 1, top view.
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Potassium voltage-gated channel subfamily KQT member 4
Chain: A
Length: 72 amino acids
Theoretical weight: 8.21 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P56696 (Residues: 522-593; Coverage: 10%)
Gene name: KCNQ4
Pfam: KCNQ voltage-gated potassium channel
InterPro:
Potassium voltage-gated channel subfamily KQT member 4 in PDB entry 4gow, assembly 1, front view.
Potassium voltage-gated channel subfamily KQT member 4 in PDB entry 4gow, assembly 1, side view.
Potassium voltage-gated channel subfamily KQT member 4 in PDB entry 4gow, assembly 1, top view.
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