› 4gow

X-ray diffraction
2.6Å resolution

Crystal Structure of Ca2+/CaM:Kv7.4 (KCNQ4) B helix complex

Released:
DOI: 10.2210/pdb4gow/pdb
PDB entry 4gow coloured by chain, front view.
PDB entry 4gow coloured by chain, side view.
PDB entry 4gow coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structure of a Ca(2+)/CaM:Kv7.4 (KCNQ4) B-helix complex provides insight into M current modulation.
Xu Q, Chang A, Tolia A, Minor DL
J Mol Biol 425 378-94 (2013)
PMID: 23178170

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-143929 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Calmodulin-1 Chain: D
Molecule details ›
Chain: D
Length: 144 amino acids
Theoretical weight: 16.33 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P0DP23 (Residues: 4-147; Coverage: 97%)
Gene names: CALM, CALM1, CAM, CAM1
Sequence domains: EF-hand domain pair
Potassium voltage-gated channel subfamily KQT member 4 Chain: A
Molecule details ›
Chain: A
Length: 72 amino acids
Theoretical weight: 8.21 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P56696 (Residues: 522-593; Coverage: 10%)
Gene name: KCNQ4
Sequence domains: KCNQ voltage-gated potassium channel

Ligands and Environments

1 bound ligand:
Ligand CA 4 x CA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRL BEAMLINE BL12-2
Spacegroup: P6522
Unit cell:
a: 104.075Å b: 104.075Å c: 113.729Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.238 0.236 0.268
Expression system: Escherichia coli

Quick links

Citations

7 review citations

KCNQ-Encoded Potassium Channels as Therapeutic Targets.
Barrese et al. (2018)
6 more

8 mentions without citation

Interfacial inhibitors.
Pommier et al. (2015)
7 more