PDB 4gq6 biological assemblies and structure analysis ‹ Protein Data Bank in Europe (PDBe)

4gq6 › Structure analysis

Human menin in complex with MLL peptide

X-ray diffraction

1.55Å resolution

Source organism: Homo sapiens

Assembly composition:

hetero dimer (preferred)

Entry contents: 2 distinct polypeptide molecules

Assembly 1 (preferred)

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Assembly Name: Menin and MLL cleavage product C180

Multimeric state: hetero dimer

Accessible surface area: 20665.41 Å²

Buried surface area: 2680.16 Å²

Dissociation area: 805.03 Å²

Dissociation energy (ΔG^diss): 4.17 kcal/mol

Dissociation entropy (TΔS^diss): 7.87 kcal/mol

Symmetry number: 1

PDBe Complex ID: PDB-CPX-126203

Chain: A
Length: 489 amino acids
Theoretical weight: 54.57 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:

Canonical: O00255 (Residues: 1-593; Coverage: 79%)
Best match: O00255-1 (Residues: 1-598)

Gene names: MEN1, SCG2
Pfam: Menin
InterPro: Menin

FASTA Sequence


    >pdb|4gq6|A

GGSSSMGLKAAQKTLFPLRSIDDVVRLFAAELGREEPDLVLLSLVLGFVEHFLAVNRVGLTYFPVADLSIIAALYARFTAQIRGAVDLSLYPREGGVSSRELVKKVSDVIWNSLSRSYFKDRAHIQSLFSFITGTKLDSSGVAFAVVGACQALGLRDVHLALSEDHAWVVFGPNGEQTAEVTWHGKGNEDRRGQTVNAGVAERSWLYLKGSYMRCDRKMEVAFMVCAINPSIDLHTDSLELLQLQQKLLWLLYDLGHLERYPMALGNLADLEELEPTPGRPDPLTLYHKGIASAKTYYRDEHIYPYMYLAGYHCRNRNVREALQAWADTATVIQDYNYCREDEEIYKEFFEVANDVIPNLLKEAASLLEAGSQGSALQDPECFAHLLRFYDGICKWEEGSPTPVLHVGWATFLVQSLGRFEGQVRQKVRIVSVPAPAASPPPEGPVLTFQSEKMKGMKELLVATKINSSAIKLQLTAQSQVQMKKQKVS

PDBe-KB: UniProt Coverage View: O00255

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	UniProt
	Chains
	Domains
	Secondary structure
	Flexibility predictions
	Early folding residue predictions
	Ligand binding sites
	Interaction interfaces

UniProt

O00255

Chains

Domains

Secondary structure

Flexibility predictions

Early folding residue predictions

Ligand binding sites

Interaction interfaces

Amino acid probabilities

Data displayed by

Property

Probability

Amino acid properties

Aromatic

Polar

Hydrophobic

Negative charge

Proline

Positive charge

Cysteine

Glycine

MLL cleavage product N320

Chain: B
Length: 12 amino acids
Theoretical weight: 1.4 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt: