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T. Maritima FDTS (R174K mutant) with FAD

X-ray diffraction
2.17Å resolution
PDB entry 4gtl coloured by chain, front view.
PDB entry 4gtl coloured by chain, side view.
PDB entry 4gtl coloured by chain, top view.
Source organism: Thermotoga maritima MSB8
Assembly composition:
homo tetramer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Flavin-dependent thymidylate synthase
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Multimeric state: homo tetramer
Accessible surface area: 34741.51 Å2
Buried surface area: 18661.62 Å2
Dissociation area: 3,903.69 Å2
Dissociation energy (ΔGdiss): 36.91 kcal/mol
Dissociation entropy (TΔSdiss): 15.1 kcal/mol
Symmetry number: 4
PDBe Complex ID: PDB-CPX-194544

Macromolecules

Flavin-dependent thymidylate synthase
Chains: A, B, C, D
Length: 232 amino acids
Theoretical weight: 27.48 KDa
Source organism: Thermotoga maritima MSB8
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9WYT0 (Residues: 1-220; Coverage: 100%)
Gene names: TM_0449, thy1, thyX
Pfam: Thymidylate synthase complementing protein
InterPro:
CATH: Gyrase A; domain 2
Flavin-dependent thymidylate synthase in PDB entry 4gtl, assembly 1, front view.
Flavin-dependent thymidylate synthase in PDB entry 4gtl, assembly 1, side view.
Flavin-dependent thymidylate synthase in PDB entry 4gtl, assembly 1, top view.
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