› › Structure analysis

R283K DNA polymerase beta ternary complex with a templating 8OG and incoming dCTP analog

X-ray diffraction
2.2Å resolution
PDB entry 4gxj coloured by chain, front view.
PDB entry 4gxj coloured by chain, side view.
PDB entry 4gxj coloured by chain, top view.
Source organisms:
Assembly composition:
hetero tetramer (preferred)
Entry contents: 1 distinct polypeptide molecule
3 distinct DNA molecules

Quick links

Assemblies

Assembly 1 (preferred)
Download    3D Visualisation
Assembly Name: DNA polymerase beta and DNA
hide full assembly name
Multimeric state: hetero tetramer
Accessible surface area: 18962.62 Å2
Buried surface area: 6275.43 Å2
Dissociation area: 652.85 Å2
Dissociation energy (ΔGdiss): 17.37 kcal/mol
Dissociation entropy (TΔSdiss): 8.05 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-117564

Macromolecules

DNA polymerase beta
Chain: A
Length: 335 amino acids
Theoretical weight: 38.21 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P06746 (Residues: 1-335; Coverage: 100%)
Gene name: POLB
Pfam:
InterPro:
CATH:
DNA polymerase beta in PDB entry 4gxj, assembly 1, front view.
DNA polymerase beta in PDB entry 4gxj, assembly 1, side view.
DNA polymerase beta in PDB entry 4gxj, assembly 1, top view.
PDBe-KB: UniProt Coverage View: P06746  
133550100150200250300
 
100200300
UniProt
P06746
Chains
Domains
Secondary structure
Flexibility predictions
Early folding residue predictions
Ligand binding sites
Molecule details ›

Search similar proteins

DNA chain D
Name: DNA (5'-D(P*GP*TP*CP*GP*G)-3')
Representative chains: D
Source organism: synthetic construct [32630]
Expression system: Not provided
Length: 5 nucleotides
Theoretical weight: 1.54 KDa
DNA (5'-D(P*GP*TP*CP*GP*G)-3') in PDB entry 4gxj, assembly 1, front view.
DNA (5'-D(P*GP*TP*CP*GP*G)-3') in PDB entry 4gxj, assembly 1, side view.
DNA (5'-D(P*GP*TP*CP*GP*G)-3') in PDB entry 4gxj, assembly 1, top view.
151.01.52.02.53.03.54.04.55.0
 
246GTCGG
Chains
Chain B (auth D)
Ligand binding sites
Interaction interfaces
Molecule details ›

Search similar DNA

DNA chain P
Name: DNA (5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*A)-3')
Representative chains: P
Source organism: synthetic construct [32630]
Expression system: Not provided
Length: 10 nucleotides
Theoretical weight: 3.09 KDa
DNA (5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*A)-3') in PDB entry 4gxj, assembly 1, front view.
DNA (5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*A)-3') in PDB entry 4gxj, assembly 1, side view.
DNA (5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*A)-3') in PDB entry 4gxj, assembly 1, top view.
11012345678910
 
510GCTGATGCGA
Chains
RSRZ Outlier Chain C (auth P)
Chain C (auth P)
Ligand binding sites
Interaction interfaces
Molecule details ›

Search similar DNA

DNA chain T
Name: DNA (5'-D(*CP*CP*GP*AP*CP*(8OG)P*TP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3')
Representative chains: T
Source organism: synthetic construct [32630]
Expression system: Not provided
Length: 16 nucleotides
Theoretical weight: 4.86 KDa
DNA (5'-D(*CP*CP*GP*AP*CP*(8OG)P*TP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3') in PDB entry 4gxj, assembly 1, front view.
DNA (5'-D(*CP*CP*GP*AP*CP*(8OG)P*TP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3') in PDB entry 4gxj, assembly 1, side view.
DNA (5'-D(*CP*CP*GP*AP*CP*(8OG)P*TP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3') in PDB entry 4gxj, assembly 1, top view.
116246810121416
 
51015CCGAC*TCGCATCAGC
Chains
RSRZ Outlier Chain D (auth T)
Chain D (auth T)
Ligand binding sites
Interaction interfaces
Molecule details ›

Search similar DNA

Quick links