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Complex structure 4 of DAXX(E225A)/H3.3(sub5)/H4

X-ray diffraction
1.95Å resolution
PDB entry 4h9q coloured by chain, front view.
PDB entry 4h9q coloured by chain, side view.
PDB entry 4h9q coloured by chain, top view.
Source organism: Homo sapiens
Assemblies composition:
hetero trimer (preferred)
hetero hexamer
Entry contents: 3 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Multimeric state: hetero trimer
Accessible surface area: 18928.49 Å2
Buried surface area: 14961.36 Å2
Dissociation area: 3,644.97 Å2
Dissociation energy (ΔGdiss): 56.01 kcal/mol
Dissociation entropy (TΔSdiss): 12.53 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-158676
Assembly 2
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Multimeric state: hetero hexamer
Accessible surface area: 36349.97 Å2
Buried surface area: 31430.08 Å2
Dissociation area: 8,046.38 Å2
Dissociation energy (ΔGdiss): 108.3 kcal/mol
Dissociation entropy (TΔSdiss): 39.35 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-158695

Macromolecules

Histone H3.3
Chain: A
Length: 135 amino acids
Theoretical weight: 15.26 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P84243 (Residues: 2-136; Coverage: 99%)
Gene names: H3-3A, H3-3B, H3.3A, H3.3B, H3F3, H3F3A, H3F3B, PP781
Pfam: Core histone H2A/H2B/H3/H4
InterPro:
CATH: Histone, subunit A
Histone H3.3 in PDB entry 4h9q, assembly 1, front view.
Histone H3.3 in PDB entry 4h9q, assembly 1, side view.
Histone H3.3 in PDB entry 4h9q, assembly 1, top view.
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Histone H4
Chain: B
Length: 102 amino acids
Theoretical weight: 11.26 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P62805 (Residues: 2-103; Coverage: 99%)
Gene names: H4-16, H4/A, H4/B, H4/C, H4/D, H4/E, H4/G, H4/H, H4/I, H4/J, H4/K, H4/M, H4/N, H4/O, H4C1, H4C11, H4C12, H4C13, H4C14, H4C15, H4C16, H4C2, H4C3, H4C4, H4C5, H4C6, H4C8, H4C9, H4F2, H4FA, H4FB, H4FC, H4FD, H4FE, H4FG, H4FH, H4FI, H4FJ, H4FK, H4FM, H4FN, H4FO, HIST1H4A, HIST1H4B, HIST1H4C, HIST1H4D, HIST1H4E, HIST1H4F, HIST1H4H, HIST1H4I, HIST1H4J, HIST1H4K, HIST1H4L, HIST2H4, HIST2H4A, HIST2H4B, HIST4H4
Pfam: Centromere kinetochore component CENP-T histone fold
InterPro:
CATH: Histone, subunit A
Histone H4 in PDB entry 4h9q, assembly 1, front view.
Histone H4 in PDB entry 4h9q, assembly 1, side view.
Histone H4 in PDB entry 4h9q, assembly 1, top view.
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Death domain-associated protein 6
Chain: C
Length: 212 amino acids
Theoretical weight: 24.67 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9UER7 (Residues: 178-389; Coverage: 29%)
Gene names: BING2, DAP6, DAXX
Pfam: Death domain-associated protein 6, histone binding domain
InterPro:
CATH: Methane Monooxygenase Hydroxylase; Chain G, domain 1
Death domain-associated protein 6 in PDB entry 4h9q, assembly 1, front view.
Death domain-associated protein 6 in PDB entry 4h9q, assembly 1, side view.
Death domain-associated protein 6 in PDB entry 4h9q, assembly 1, top view.
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