Structure analysis

Crystal Structure of HIV-1 protease mutants D30N complexed with inhibitor GRL-0519

X-ray diffraction
1.49Å resolution
Assembly composition:
homo dimer (preferred)
Entry contents: 1 distinct polypeptide molecule

Assemblies

Assembly 1 (preferred)
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Multimeric state: homo dimer
Accessible surface area: 9522.97 Å2
Buried surface area: 4353.99 Å2
Dissociation area: 2,002.09 Å2
Dissociation energy (ΔGdiss): 27.24 kcal/mol
Dissociation entropy (TΔSdiss): 11.44 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-136860

Macromolecules

Chains: A, B
Length: 99 amino acids
Theoretical weight: 10.74 KDa
Source organism: Human immunodeficiency virus type 1 (BRU ISOLATE)
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P03367 (Residues: 501-599; Coverage: 7%)
Gene name: gag-pol
Pfam: Retroviral aspartyl protease
InterPro:
CATH: Acid Proteases

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