› › Structure analysis

Structure of the variant histone H3.3-H4 heterodimer in complex with its chaperone DAXX

X-ray diffraction
2.799Å resolution
PDB entry 4hga coloured by chain, front view.
PDB entry 4hga coloured by chain, side view.
PDB entry 4hga coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero trimer (preferred)
Entry contents: 3 distinct polypeptide molecules

Quick links

Assemblies

Assembly 1 (preferred)
Download    3D Visualisation
Multimeric state: hetero trimer
Accessible surface area: 18072.51 Å2
Buried surface area: 13932.39 Å2
Dissociation area: 3,608.04 Å2
Dissociation energy (ΔGdiss): 65.46 kcal/mol
Dissociation entropy (TΔSdiss): 12.35 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-158676

Macromolecules

Death domain-associated protein 6
Chain: A
Length: 213 amino acids
Theoretical weight: 24.81 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9UER7 (Residues: 184-390; Coverage: 28%)
Gene names: BING2, DAP6, DAXX
Pfam: Death domain-associated protein 6, histone binding domain
InterPro:
CATH: Methane Monooxygenase Hydroxylase; Chain G, domain 1
Death domain-associated protein 6 in PDB entry 4hga, assembly 1, front view.
Death domain-associated protein 6 in PDB entry 4hga, assembly 1, side view.
Death domain-associated protein 6 in PDB entry 4hga, assembly 1, top view.
Molecule details ›

Search similar proteins

Histone H3.3
Chain: B
Length: 136 amino acids
Theoretical weight: 15.36 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P84243 (Residues: 1-136; Coverage: 100%)
Gene names: H3-3A, H3-3B, H3.3A, H3.3B, H3F3, H3F3A, H3F3B, PP781
Pfam: Core histone H2A/H2B/H3/H4
InterPro:
CATH: Histone, subunit A
Histone H3.3 in PDB entry 4hga, assembly 1, front view.
Histone H3.3 in PDB entry 4hga, assembly 1, side view.
Histone H3.3 in PDB entry 4hga, assembly 1, top view.
Molecule details ›

Search similar proteins

Histone H4
Chain: C
Length: 103 amino acids
Theoretical weight: 11.39 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P62805 (Residues: 1-103; Coverage: 100%)
Gene names: H4-16, H4/A, H4/B, H4/C, H4/D, H4/E, H4/G, H4/H, H4/I, H4/J, H4/K, H4/M, H4/N, H4/O, H4C1, H4C11, H4C12, H4C13, H4C14, H4C15, H4C16, H4C2, H4C3, H4C4, H4C5, H4C6, H4C8, H4C9, H4F2, H4FA, H4FB, H4FC, H4FD, H4FE, H4FG, H4FH, H4FI, H4FJ, H4FK, H4FM, H4FN, H4FO, HIST1H4A, HIST1H4B, HIST1H4C, HIST1H4D, HIST1H4E, HIST1H4F, HIST1H4H, HIST1H4I, HIST1H4J, HIST1H4K, HIST1H4L, HIST2H4, HIST2H4A, HIST2H4B, HIST4H4
Pfam: Centromere kinetochore component CENP-T histone fold
InterPro:
CATH: Histone, subunit A
Histone H4 in PDB entry 4hga, assembly 1, front view.
Histone H4 in PDB entry 4hga, assembly 1, side view.
Histone H4 in PDB entry 4hga, assembly 1, top view.
Molecule details ›

Search similar proteins

Quick links