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Pyruvate kinase (PYK) from Trypanosoma brucei in the presence of Magnesium and F26BP

X-ray diffraction
2.35Å resolution
PDB entry 4hyw coloured by chain, front view.
PDB entry 4hyw coloured by chain, side view.
PDB entry 4hyw coloured by chain, top view.
Source organism: Trypanosoma brucei brucei
Assembly composition:
homo tetramer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Pyruvate kinase 1
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Multimeric state: homo tetramer
Accessible surface area: 72951.36 Å2
Buried surface area: 18972.35 Å2
Dissociation area: 7,308.44 Å2
Dissociation energy (ΔGdiss): 79.36 kcal/mol
Dissociation entropy (TΔSdiss): 46.25 kcal/mol
Symmetry number: 4
PDBe Complex ID: PDB-CPX-151771

Macromolecules

Pyruvate kinase 1
Chains: A, B
Length: 499 amino acids
Theoretical weight: 54.54 KDa
Source organism: Trypanosoma brucei brucei
Expression system: Escherichia coli
UniProt:
  • Canonical: P30615 (Residues: 1-499; Coverage: 100%)
Gene name: PYK1
Pfam:
InterPro:
CATH:
Pyruvate kinase 1 in PDB entry 4hyw, assembly 1, front view.
Pyruvate kinase 1 in PDB entry 4hyw, assembly 1, side view.
Pyruvate kinase 1 in PDB entry 4hyw, assembly 1, top view.
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