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Room temperature X-ray Structure of cAMP dependent protein kinase A in complex with high Sr2+ concentration, ADP and phosphorylated peptide pSP20

X-ray diffraction
2Å resolution
PDB entry 4iay coloured by chain, front view.
PDB entry 4iay coloured by chain, side view.
PDB entry 4iay coloured by chain, top view.
Source organisms:
Assembly composition:
hetero dimer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: cAMP-dependent protein kinase catalytic subunit alpha and cAMP-dependent protein kinase inhibitor alpha
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Multimeric state: hetero dimer
Accessible surface area: 15879.19 Å2
Buried surface area: 3440.69 Å2
Dissociation area: 1,121.87 Å2
Dissociation energy (ΔGdiss): 24.2 kcal/mol
Dissociation entropy (TΔSdiss): 9.25 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-138544

Macromolecules

cAMP-dependent protein kinase catalytic subunit alpha
Chain: A
Length: 356 amino acids
Theoretical weight: 41.57 KDa
Source organism: Mus musculus
Expression system: Escherichia coli
UniProt:
  • Canonical: P05132 (Residues: 2-351; Coverage: 100%)
Gene names: Pkaca, Prkaca
Pfam: Protein kinase domain
InterPro:
CATH:
cAMP-dependent protein kinase catalytic subunit alpha in PDB entry 4iay, assembly 1, front view.
cAMP-dependent protein kinase catalytic subunit alpha in PDB entry 4iay, assembly 1, side view.
cAMP-dependent protein kinase catalytic subunit alpha in PDB entry 4iay, assembly 1, top view.
PDBe-KB: UniProt Coverage View: P05132  
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cAMP-dependent protein kinase inhibitor alpha
Chain: S
Length: 20 amino acids
Theoretical weight: 2.28 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P61925 (Residues: 6-25; Coverage: 26%)
Gene names: PKIA, PRKACN1
InterPro: cAMP-dependent protein kinase inhibitor
cAMP-dependent protein kinase inhibitor alpha in PDB entry 4iay, assembly 1, front view.
cAMP-dependent protein kinase inhibitor alpha in PDB entry 4iay, assembly 1, side view.
cAMP-dependent protein kinase inhibitor alpha in PDB entry 4iay, assembly 1, top view.
PDBe-KB: UniProt Coverage View: P61925  
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