EC 2.4.2.8: Hypoxanthine phosphoribosyltransferase
Reaction catalysed:
IMP + diphosphate = hypoxanthine + 5-phospho-alpha-D-ribose 1-diphosphate
Systematic name:
IMP:diphosphate phospho-D-ribosyltransferase
Alternative Name(s):
- 6-hydroxypurine phosphoribosyltransferase
- 6-mercaptopurine phosphoribosyltransferase
- GMP pyrophosphorylase
- GPRT
- Guanine phosphoribosyltransferase
- Guanine-hypoxanthine phosphoribosyltransferase
- Guanosine 5'-phosphate pyrophosphorylase
- Guanosine phosphoribosyltransferase
- Guanylate pyrophosphorylase
- Guanylic pyrophosphorylase
- HGPRTase
- HPRT
- Hypoxanthine-guanine phosphoribosyltransferase
- IMP diphosphorylase
- IMP pyrophosphorylase
- IMP-GMP pyrophosphorylase
- Inosinate pyrophosphorylase
- Inosine 5'-phosphate pyrophosphorylase
- Inosinic acid pyrophosphorylase
- Inosinic pyrophosphorylase
- Purine-6-thiol phosphoribosyltransferase
- Transphosphoribosidase
GO terms
Biochemical function:
Biological process:
- dopaminergic neuron differentiation
- protein homotetramerization
- dendrite morphogenesis
- lymphocyte proliferation
- hypoxanthine metabolic process
- adenine metabolic process
- IMP metabolic process
- GMP catabolic process
- positive regulation of dopamine metabolic process
- AMP salvage
- hypoxanthine salvage
- dopamine metabolic process
- IMP salvage
- GMP salvage
- central nervous system neuron development
- cerebral cortex neuron differentiation
- striatum development
- locomotory behavior
- grooming behavior
- guanine salvage
- purine ribonucleoside salvage
- purine nucleotide biosynthetic process
- response to amphetamine
- T cell mediated cytotoxicity
Protein family (Pfam)
InterPro annotations
CATH domain