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Human hypoxanthine-guanine phosphoribosyltransferase in complex with [(2-((Guanine-9H-yl)methyl)propane-1,3-diyl)bis(oxy)]bis(methylene))diphosphonic acid

X-ray diffraction
2.004Å resolution
PDB entry 4ijq coloured by chain, front view.
PDB entry 4ijq coloured by chain, side view.
PDB entry 4ijq coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
homo tetramer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Hypoxanthine-guanine phosphoribosyltransferase
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Multimeric state: homo tetramer
Accessible surface area: 29685.86 Å2
Buried surface area: 12784.79 Å2
Dissociation area: 2,197.04 Å2
Dissociation energy (ΔGdiss): 6.97 kcal/mol
Dissociation entropy (TΔSdiss): 14.18 kcal/mol
Symmetry number: 4
PDBe Complex ID: PDB-CPX-132564

Macromolecules

Hypoxanthine-guanine phosphoribosyltransferase
Chains: A, B, C, D
Length: 223 amino acids
Theoretical weight: 25.31 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P00492 (Residues: 2-218; Coverage: 100%)
Gene names: HPRT, HPRT1
Pfam: Phosphoribosyl transferase domain
InterPro:
CATH: Rossmann fold
Hypoxanthine-guanine phosphoribosyltransferase in PDB entry 4ijq, assembly 1, front view.
Hypoxanthine-guanine phosphoribosyltransferase in PDB entry 4ijq, assembly 1, side view.
Hypoxanthine-guanine phosphoribosyltransferase in PDB entry 4ijq, assembly 1, top view.
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