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N10-formyltetrahydrofolate synthetase from Moorella thermoacetica with ADP/ZD9 and XPO

X-ray diffraction
2.563Å resolution
PDB entry 4iol coloured by chain, front view.
PDB entry 4iol coloured by chain, side view.
PDB entry 4iol coloured by chain, top view.
Source organism: Moorella thermoacetica ATCC 39073
Assembly composition:
homo tetramer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Formate--tetrahydrofolate ligase
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Multimeric state: homo tetramer
Accessible surface area: 73242.16 Å2
Buried surface area: 18135.45 Å2
Dissociation area: 1,111.28 Å2
Dissociation energy (ΔGdiss): -0.45 kcal/mol
Dissociation entropy (TΔSdiss): 15.97 kcal/mol
Symmetry number: 4
PDBe Complex ID: PDB-CPX-173900

Macromolecules

Formate--tetrahydrofolate ligase
Chains: A, B
Length: 559 amino acids
Theoretical weight: 60.01 KDa
Source organism: Moorella thermoacetica ATCC 39073
Expression system: Escherichia coli
UniProt:
  • Canonical: Q2RM91 (Residues: 1-559; Coverage: 100%)
Gene names: Moth_0109, fhs
Pfam: Formate--tetrahydrofolate ligase
InterPro:
CATH:
Formate--tetrahydrofolate ligase in PDB entry 4iol, assembly 1, front view.
Formate--tetrahydrofolate ligase in PDB entry 4iol, assembly 1, side view.
Formate--tetrahydrofolate ligase in PDB entry 4iol, assembly 1, top view.
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