Structure analysis

Crystal Structure of Matriptase in complex with its inhibitor HAI-1

X-ray diffraction
2.01Å resolution
Source organism: Homo sapiens
Assembly composition:
hetero dimer (preferred)
Entry contents: 2 distinct polypeptide molecules

Assemblies

Assembly 1 (preferred)
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Multimeric state: hetero dimer
Accessible surface area: 12896.43 Å2
Buried surface area: 4383.8 Å2
Dissociation area: 1,167.82 Å2
Dissociation energy (ΔGdiss): 5.01 kcal/mol
Dissociation entropy (TΔSdiss): 10.78 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-128881

Macromolecules

Chain: A
Length: 241 amino acids
Theoretical weight: 26.48 KDa
Source organism: Homo sapiens
Expression system: Komagataella pastoris
UniProt:
  • Canonical: Q9Y5Y6 (Residues: 615-855; Coverage: 28%)
Gene names: PRSS14, SNC19, ST14, TADG15
Pfam: Trypsin
InterPro:
CATH: Trypsin-like serine proteases
PDBe-KB: UniProt Coverage View: Q9Y5Y6  
124120406080100120140160180200220240
 
100200VVGGTDADEGEWPWQVSLHALGQGHICGASLISPNWLVSAAHCYIDDRGFRYSDPTQWTAFLGLHDQSQRSAPGVQERRLKRIISHPFFNDFTFDYDIALLELEKPAEYSSMVRPICLPDASHVFPAGKAIWVTGWGHTQYGGTGALILQKGEIRVIQQTTCENLLPQQITPRMMCVGFLSGGVDSCQGDSGGPLSSVEADGRIFQAGVVSWGDGCAQRNKPGVYTRLPLFRDWIKENTGV
UniProt
Q9Y5Y6
Chains
Domains
Secondary structure
Flexibility predictions
Early folding residue predictions
Ligand binding sites
Sequence conservation

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Chain: B
Length: 60 amino acids
Theoretical weight: 6.94 KDa
Source organism: Homo sapiens
Expression system: Drosophila melanogaster
UniProt:
  • Canonical: O43278 (Residues: 245-304; Coverage: 12%)
Gene names: HAI1, SPINT1, UNQ223/PRO256
Pfam: Kunitz/Bovine pancreatic trypsin inhibitor domain
InterPro:
CATH: Pancreatic trypsin inhibitor Kunitz domain
PDBe-KB: UniProt Coverage View: O43278  
16051015202530354045505560
 
204060QTEDYCLASNKVGRCRGSFPRWYYDPTEQICKSFVYGGCLGNKNNYLREEECILACRGVQ
UniProt
O43278
Chains
Domains
Secondary structure
Flexibility predictions
Early folding residue predictions
Ligand binding sites
Sequence conservation

Search similar proteins