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Crystals structure of Human Glucokinase in complex with small molecule activator

X-ray diffraction
2.1Å resolution
PDB entry 4iwv coloured by chain, front view.
PDB entry 4iwv coloured by chain, side view.
PDB entry 4iwv coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Hexokinase-4
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Multimeric state: monomeric
Accessible surface area: 17575.68 Å2
Buried surface area: 513.08 Å2
Dissociation area: 191.05 Å2
Dissociation energy (ΔGdiss): -0.78 kcal/mol
Dissociation entropy (TΔSdiss): 2.52 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-152941

Macromolecules

Hexokinase-4
Chain: A
Length: 456 amino acids
Theoretical weight: 50.81 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P35557 (Residues: 15-465; Coverage: 97%)
Gene name: GCK
Pfam:
InterPro:
CATH:
Hexokinase-4 in PDB entry 4iwv, assembly 1, front view.
Hexokinase-4 in PDB entry 4iwv, assembly 1, side view.
Hexokinase-4 in PDB entry 4iwv, assembly 1, top view.
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