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Crystal Structure of Respiratory Syncytial Virus Fusion Glycoprotein Stabilized in the Prefusion Conformation by Human Antibody D25

Source organisms:
Biochemical function: not assigned
Biological process: fusion of virus membrane with host plasma membrane
Cellular component: not assigned

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GO terms

Biochemical function:
  • not assigned
Biological process:
Cellular component:
  • not assigned

Sequence family

Pfam Protein family (Pfam)
PF00523
Domain description: Fusion glycoprotein F0
Occurring in:
  1. Fusion glycoprotein F0
The deposited structure of PDB entry 4jhw contains 1 copy of Pfam domain PF00523 (Fusion glycoprotein F0) in Fusion glycoprotein F0. Showing 1 copy in chain C [auth F].

InterPro InterPro annotations
IPR003597
Domain description: Immunoglobulin C1-set
Occurring in:
  1. D25 antigen-binding fragment heavy chain
  2. D25 light chain
IPR013106
Domain description: Immunoglobulin V-set domain
Occurring in:
  1. D25 antigen-binding fragment heavy chain
  2. D25 light chain
IPR036179
Domain description: Immunoglobulin-like domain superfamily
Occurring in:
  1. D25 antigen-binding fragment heavy chain
  2. D25 light chain
IPR013783
Domain description: Immunoglobulin-like fold
Occurring in:
  1. D25 antigen-binding fragment heavy chain
  2. D25 light chain
IPR007110
Domain description: Immunoglobulin-like domain
Occurring in:
  1. D25 antigen-binding fragment heavy chain
  2. D25 light chain
IPR003599
Domain description: Immunoglobulin domain subtype
Occurring in:
  1. D25 antigen-binding fragment heavy chain
  2. D25 light chain
IPR003006
Domain description: Immunoglobulin/major histocompatibility complex, conserved site
Occurring in:
  1. D25 antigen-binding fragment heavy chain
  2. D25 light chain
IPR012473
Domain description: Fibritin C-terminal
Occurring in:
  1. Fusion glycoprotein F0
IPR000776
Domain description: Precursor fusion glycoprotein F0, Paramyxoviridae
Occurring in:
  1. Fusion glycoprotein F0

Structure domain

CATH CATH domain
2.60.40.10
Class: Mainly Beta
Architecture: Sandwich
Topology: Immunoglobulin-like
Homology: Immunoglobulins
Occurring in:
  1. D25 antigen-binding fragment heavy chain
  2. D25 light chain
The deposited structure of PDB entry 4jhw contains 2 copies of CATH domain 2.60.40.10 (Immunoglobulin-like) in D25 antigen-binding fragment heavy chain. Showing 2 copies in chain A [auth H].
The deposited structure of PDB entry 4jhw contains 2 copies of CATH domain 2.60.40.10 (Immunoglobulin-like) in D25 light chain. Showing 2 copies in chain B [auth L].

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