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Crystal structure of hcv ns5b polymerase in complex with compound 24

X-ray diffraction
2.2Å resolution
PDB entry 4ju6 coloured by chain, front view.
PDB entry 4ju6 coloured by chain, side view.
PDB entry 4ju6 coloured by chain, top view.
Source organism: Hepatitis C virus isolate HC-J4
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: RNA-directed RNA polymerase
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Multimeric state: monomeric
Accessible surface area: 23104.54 Å2
Buried surface area: 110.24 Å2
Dissociation area: 55.12 Å2
Dissociation energy (ΔGdiss): 8.24 kcal/mol
Dissociation entropy (TΔSdiss): -1.46 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-131655
Assembly 2
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Assembly Name: RNA-directed RNA polymerase
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Multimeric state: monomeric
Accessible surface area: 23329.12 Å2
Buried surface area: 75.93 Å2
Dissociation area: 37.96 Å2
Dissociation energy (ΔGdiss): 4.87 kcal/mol
Dissociation entropy (TΔSdiss): -1.47 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-131655

Macromolecules

RNA-directed RNA polymerase
Chains: A, B
Length: 576 amino acids
Theoretical weight: 64.29 KDa
Source organism: Hepatitis C virus isolate HC-J4
Expression system: Escherichia coli
UniProt:
  • Canonical: O92972 (Residues: 2420-2989; Coverage: 19%)
Pfam: Viral RNA dependent RNA polymerase
InterPro:
RNA-directed RNA polymerase in PDB entry 4ju6, assembly 1, front view.
RNA-directed RNA polymerase in PDB entry 4ju6, assembly 1, side view.
RNA-directed RNA polymerase in PDB entry 4ju6, assembly 1, top view.
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