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Ternary crystal structures of human DNA POLYMERASE LAMBDA IN COMPLEX WITH DNA AND L-DCTP.

X-ray diffraction
2.15Å resolution
PDB entry 4k4g coloured by chain, front view.
PDB entry 4k4g coloured by chain, side view.
PDB entry 4k4g coloured by chain, top view.
Source organisms:
Assembly composition:
hetero tetramer (preferred)
Entry contents: 1 distinct polypeptide molecule
3 distinct DNA molecules

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Assemblies

Assembly 1
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Assembly Name: DNA polymerase lambda and DNA
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Multimeric state: hetero tetramer
Accessible surface area: 18026.46 Å2
Buried surface area: 5005.34 Å2
Dissociation area: 1,385.05 Å2
Dissociation energy (ΔGdiss): 26.21 kcal/mol
Dissociation entropy (TΔSdiss): 10.32 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-117719
Assembly 2
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Assembly Name: DNA polymerase lambda and DNA
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Multimeric state: hetero tetramer
Accessible surface area: 17652.51 Å2
Buried surface area: 4915.12 Å2
Dissociation area: 632.57 Å2
Dissociation energy (ΔGdiss): 15.41 kcal/mol
Dissociation entropy (TΔSdiss): 7.63 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-117719
Assembly 3
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Assembly Name: DNA polymerase lambda and DNA
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Multimeric state: hetero tetramer
Accessible surface area: 18345.68 Å2
Buried surface area: 4645.96 Å2
Dissociation area: 1,130.95 Å2
Dissociation energy (ΔGdiss): 14.42 kcal/mol
Dissociation entropy (TΔSdiss): 10.2 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-117719
Assembly 4 (preferred)
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Assembly Name: DNA polymerase lambda and DNA
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Multimeric state: hetero tetramer
Accessible surface area: 18617.72 Å2
Buried surface area: 4457.73 Å2
Dissociation area: 1,103.16 Å2
Dissociation energy (ΔGdiss): 15.87 kcal/mol
Dissociation entropy (TΔSdiss): 10.21 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-117719

Macromolecules

DNA polymerase lambda
Chains: A, E, I, M
Length: 340 amino acids
Theoretical weight: 38.25 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9UGP5 (Residues: 245-575; Coverage: 58%)
Gene name: POLL
Pfam:
InterPro:
CATH:
DNA polymerase lambda in PDB entry 4k4g, assembly 4, front view.
DNA polymerase lambda in PDB entry 4k4g, assembly 4, side view.
DNA polymerase lambda in PDB entry 4k4g, assembly 4, top view.
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DNA chains B, F, J, N
Name: DNA (5'-D(*CP*GP*GP*CP*GP*GP*TP*AP*CP*TP*G)-3')
Representative chains: B, F, J, N
Source organism: synthetic construct [32630]
Expression system: Not provided
Length: 11 nucleotides
Theoretical weight: 3.39 KDa
DNA (5'-D(*CP*GP*GP*CP*GP*GP*TP*AP*CP*TP*G)-3') in PDB entry 4k4g, assembly 4, front view.
DNA (5'-D(*CP*GP*GP*CP*GP*GP*TP*AP*CP*TP*G)-3') in PDB entry 4k4g, assembly 4, side view.
DNA (5'-D(*CP*GP*GP*CP*GP*GP*TP*AP*CP*TP*G)-3') in PDB entry 4k4g, assembly 4, top view.
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DNA chains C, G, K, O
Name: DNA (5'-D(*CP*AP*GP*TP*AP*C)-3')
Representative chains: C, G, K, O
Source organism: synthetic construct [32630]
Expression system: Not provided
Length: 6 nucleotides
Theoretical weight: 1.79 KDa
DNA (5'-D(*CP*AP*GP*TP*AP*C)-3') in PDB entry 4k4g, assembly 4, front view.
DNA (5'-D(*CP*AP*GP*TP*AP*C)-3') in PDB entry 4k4g, assembly 4, side view.
DNA (5'-D(*CP*AP*GP*TP*AP*C)-3') in PDB entry 4k4g, assembly 4, top view.
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DNA chains D, H, L, P
Name: DNA (5'-D(P*GP*CP*CP*G)-3')
Representative chains: D, H, L, P
Source organism: synthetic construct [32630]
Expression system: Not provided
Length: 4 nucleotides
Theoretical weight: 1.19 KDa
DNA (5'-D(P*GP*CP*CP*G)-3') in PDB entry 4k4g, assembly 4, front view.
DNA (5'-D(P*GP*CP*CP*G)-3') in PDB entry 4k4g, assembly 4, side view.
DNA (5'-D(P*GP*CP*CP*G)-3') in PDB entry 4k4g, assembly 4, top view.
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